Boopatherajan, K (2020) A Cross Sectional study of Prevalence of Malignancy in Solitary Nodule of Thyroid. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
BACKGROUND: The prevalence of Solitary nodule of thyroid has increased in the present day as compared to two decades before. Due to the possibility of malignant change, some clinicians especially those in surgical subspecialities recommended that all nodules have to be surgically removed. AIM OF THE STUDY: 1. To investigate the prevalence of solitary nodule thryroid at Government Royapettah hospital Chennai. 2. To evaluate the prevalence of adenoma and carcinoma as a cause for solitary nodule of thyroid. 3. To determine the percentage of solitary nodule of thyroid turning out to be malignant. 4. To determine the association of solitary nodule of thyroid with age and sex. 5. To investigate thyroid hormone profile and status in patient with solitary nodule of thyroid. 6. To determine the role of Fine needle aspiration cytology in solitary nodule of thyroid. MATERIALS AND METHODS: This study was a prospective nonrandomized hospital based observational study carried out in 50 patients who presented clinically with solitary nodule of thyroid who attended the outpatient department of the department of general surgery, Government Royapettah hospital, Chennai. Inclusion Criteria: 1. Patients of age more than 18 of both the genders. 2. Patients attending the outpatient department or admitted for surgery, with clinical or radiologically detected solitary nodule admitted at department of the general surgery , Government Royapettah hospital. Exclusion Criteria: 1. Patients with age less than 18 years. 2. Patients with previous history of head and neck irradiation. 3. Patients who did not consent for the study. 4. Patients with diffuse thyroid swelling. RESULTS: Commonest presentation of solitary thyroid nodule was swelling in the thyroid region. The Peak incidence of solitary nodule was observed in 2nd to 3rd decade, constituting 60% of the cases studied. Females predominated in number over males in occurrence of solitary nodule in ratio of 1:11.5. 36% of all clinically solitary nodule turned out to be colloid nodule. The common causes of solitary nodule was colloid nodule (36%), multinodular goiter (26%), follicular adenoma(22%). 86% 0f cases presented with euthyroid state. Incidence of malignancy in solitary thyroid nodule was 12%. Incidence of carcinoma in males presenting as solitary nodule was higher (25%) compared to that of females (10.87%). The most common cause of malignancy was papillary carcinoma (67%) followed by follicular carcinoma (33%). CONCLUSION: Solitary nodule of thyroid is more common in 2nd to 3rd decades. Solitary nodule of thyroid are more common in females. Most of the patients presenting with solitary nodule of thyroid are euthyroid and only a small percentage of patient with symptoms of toxicity or hypothyroidism USG can be accurately used to detect patients with multinodulary goiter who clinically present as solitary nodule of thyroid. Common causes of solitary nodule of thyroid are colloid nodule, MNG and follicular adenoma. Incidence of malignancy in male patients presenting with solitary nodule of thyroid is more when compared to female. The most common cause of malignancy in solitary nodule is papillary carcinoma followed by follicular carcinoma.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711153 |
| Uncontrolled Keywords: | solitary nodule, malignancy, colloid nodule, euthyroid, papillary carcinoma. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 10 Feb 2021 15:38 |
| Last Modified: | 10 Feb 2021 15:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13986 |
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