Senthil, M (2020) A Comparative study on Effect of Centchroman on Mastalgias and Fibroadenomas. Masters thesis, Madurai Medical College, Madurai.
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Abstract
AIMS AND OBJECTIVES: Centchroman (Ormeloxifene) is a selective oestrogen receptor modulators (SERM), acting selectively on oestrogen receptor. Hence it has been used for treatment of mastalgia and fibroadenoma. MATERIALS AND METHODS: Benign breast disease patients attending surgery outpatient department from August 2018 to August 2019, fulfilling inclusion criterion were included in the study. They were started on centchroman 30 mg single dose on alternative days for a period of 24 weeks and were assessed at 4, 8, 12, and 24 weeks. The Results were recorded as per clinical examination, ultrasonography for breast lump and visual analog scale (VAS) for pain. RESULTS: A total of 60 patients were included in the study, 30 (50%) with mastalgia and 30 (50%) with fibroadenoma, and further randomly categorised into study (15/30) and control (15/30) groups. At the end of 24 weeks in study group, 12/15 (80%) patients of fibroadenoma had complete regression whereas in mastalgia group, 12/15 (80%) had complete resolution of pain. Only 4/30 (13.3%) patients had menstrual delay as side effect. CONCLUSIONS: Centchroman is effective, safe and inexpensive showing good results in mastalgia and fibroadenoma,
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221711124 |
| Uncontrolled Keywords: | Centchroman, Mastalgias, Fibroadenomas. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 10 Feb 2021 02:50 |
| Last Modified: | 10 Feb 2021 02:50 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13983 |
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