Sakthinesh, A (2020) Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer following 4 Cycles of AC with Cisplatin followed by 4 Cycles of Taxanes Vs 4 Cycles of AC followed by 4 Cycles of Taxanes. Masters thesis, Madurai Medical College, Madurai.
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Abstract
AIM OF THE STUDY: The aim of this study is to assess the response to neoadjuvant chemotherapy in TNBC following 4 cycles of AC with Cisplatin followed by 4 cycles of Taxanes versus 4 cycles of AC followed by 4 cycles of taxanes to study the efficacy of cisplatin as neoadjuvant chemotherapy in TNBC based on the pathologic complete response [pCR]). METHODOLOGY: This study was carried out in the Department of Surgery, Government Rajaji Hospital Madurai, during the period August 2017 to November 2019 in collaboration with Department of Medical Oncology, Government Rajaji Hospital, Madurai. The patients presenting with inoperable triple negative breast cancer with M0 (no metastasis) in GRH Madurai will be recruited for this study. Following consent, a questionnaire will be filled to record the patient's demographic data, duration of disease, symptoms, & treatment history. Patients coming to GRH, Madurai with lump breast cancer are evaluated based on receptor status, USG Abdomen, USG breast, FNAC breast, trucut biopsy from the lump, skeletal survey, routine blood investigations are done. Patient are categorised under TRIPLE NEGATIVE BREAST carcinoma based on their investigation reports. Patients are divided into group A and group B regimen. Regimen A (4 CYCLES OF AC FOLLOWED BY 4 CYCLES OF TAXANES) and Regimen B (4 CYCLES OF AC WITH CISPLATIN FOLLOWED BY 4 CYCLES OF TAXANES) will be given to the group of patients accordingly. Response to the treatment is assessed based on the tumour size, nodal status, staging and MRI. By above mentioned inclusion and exclusion criteria 60 patients had been enrolled for the study. All the women enrolled in the study were subjected to the following protocol. They had been explained about the chemotherapy regimen and insisted to attend chemotherapy regimen regularly. They had been told about surgical and radiation therapy following the neoadjuvant chemotherapy. Patients are divided into Group A (cases) and Group B (control) regimen. • Regimen A (4 Cycles of AC with Cisplatin followed by 4 cycles of Taxanes). • Regimen B (4 Cycles of AC followed by 4 Cycles of Taxanes) will be given to the group of patients accordingly. Response to the treatment is assessed based on the tumour size, nodal status, staging by MRI. CONCLUSION: From this study it is evident that cisplatin based neoadjuvant chemotherapy in locally advanced triple negative breast cancer: 1. Showed a significant increased pCR rates in patients at the cost of worse haematological toxicities. 2. It also provides an opportunity to analyze biological markers as predictors of response to CT.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221711123 |
| Uncontrolled Keywords: | Neoadjuvant Chemotherapy, Triple Negative Breast Cancer, 4 Cycles of AC, Cisplatin, 4 Cycles of Taxanes, 4 Cycles of AC, 4 Cycles of Taxanes. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 10 Feb 2021 02:46 |
| Last Modified: | 10 Feb 2021 02:46 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13982 |
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