Pushparaj, T S (2020) Prospective study on Association of Helicobacter pylori infection in Colorectal Cancer in Government Rajaji Hospital, Madurai. Masters thesis, Madurai Medical College, Madurai.
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Abstract
INTRODUCTION: Colorectal cancers hold a major burden of cancer and cancer-related deaths in the world. Colorectal cancers were studied extensively for their association with environmental and dietary factors, and gut microflora. As these include modifiable risk factors there is a potential for their role in primary prevention of colorectal cancers. Helicobacter pylori (H. pylori) being highly prevalent in general population, any evidence of its role in colorectal carcinomas will warrant early screening and eradication of this risk factor. H. pylori is known to be associated with a large spectrum of gastric and extra-gastric conditions. H. pylori has been recognized as a class I human carcinogen by the International agency for cancer research. There are recent reports on the role of H. pylori in the promotion of tumour growth in extra-gastric organs, of which its role in colorectal neoplasm is gaining interest. AIMS AND OBJECTIVES: To evaluate the association of H. pylori infection and colorectal cancers and determine the prevalence of Helicobacter pylori infection in patients with colorectal cancers. To examine the possible correlation of overall H. pylori infection and the CagA strains with the site, histopathological differentiation, stage and metastasis of colorectal cancer. METHODS: This study was carried out in the Department of General Surgery, GRH Madurai between August 2018 and August 2019. The patient considered to have H. pylori infection if either CagA ELISA test or H. pylori stool antigen test were positive. RESULTS: The present study showed that there was no association between H. pylori infection and colorectal cancers. Except for identified risk with CagA strains of H. pylori in relation to well-differentiated adenocarcinoma, there was no association of CagA strains with the site, histopathological differentiation, stage and metastasis of disease. CONCLUSION: Though our study did not show any correlation of H. pylori infection with colorectal cancers, it would add a small amount of evidence to the large pool of further research required to objectify the correlation between the two.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711121 |
| Uncontrolled Keywords: | Association, Helicobacter pylori infection, Colorectal Cancer. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 10 Feb 2021 02:35 |
| Last Modified: | 10 Feb 2021 02:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13980 |
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