Natramizh, K (2020) A Comparative study on Epidermal Grafting Vs Split Skin Grafting in Wound Healing in our Institute. Masters thesis, Stanley Medical College, Chennai.
|
Text
220100220natramizh.pdf Download (3MB) | Preview |
Abstract
INTRODUCTION: Chronic wounds are more prevalent disease with a significant healthcare burden. These wounds often do not respond to standard wound care therapy alone. It requires the use of adjuvant therapies. Epidermal grafting, previously utilized primarily for correction of Vitiligo in Dermatology, is increasingly being considered as a beneficial therapy for healing of both acute and chronic wounds. Epidermal grafting has been shown to be successful in the management of chronic wounds, with promising healing outcomes in refractory patients. It has not only been shown to be effective, but it is also associated with lower cost and morbidity when compared to traditional skin grafting techniques as well as improved healing in the donor site. This treatment modality has become more standardized, reproducible, and user friendly as well as less time consuming, through the use of the Epidermal Harvesting System , making its use in the clinical setting more easy and beneficial. Epidermal grafting represents a promising, efficacious and cost-effective option for treatment of acute and chronic non-healing wounds. OBJECTIVES: 1. To compare the efficacy and clinical outcome of Epidermal grafting and Split skin grafting in wound healing in our institute. 2. To assess time period for healing in donor site, pain score as reported by patients in numerical rating scale (0-10). METHODOLOGY: This is a Prospective randomised study that compares the efficacy and wound healing mechanism of Epidermal grafting with Split skin grafting. The primary outcome measures proportion of wound that heals in 6 weeks and donor site healing time. The secondary outcome measures pain score and patient satisfaction. Written informed consent will be obtained from all subjects before enrollment in study. Patients will be randomly allotted into two equal groups. Group A will undergo Epidermal grafting as treatment modality for wound healing. Group B will undergo Split skin grafting as the treatment modality for wound healing. Split skin grafting done using Humby knife and Epidermal grafting done using Epidermal harvesting system. All patients will be reviewed at 1st week, 2nd week, 4th week and 6th week post operatively. RESULTS: In our study the following results had been arrived: ◈ DONOR SITE PAIN SCORE: In the Epidermal grafting group, the donor site pain score is zero while in the Split Skin Grafting group, the mean donor site pain at week one is 5.4 (S.D=0.8). Donor site Pain is better in the Epidermal grafting group. ◈ DONOR SITE HEALING: In the Epidermal grafting group, the mean donor site healing is 98.28% (S.D=1.46%) while in the Split Skin Grafting group, the mean donor site healing is 86% (S.D=4.9%). Donor site healing is better with Epidermal grafting group. Student t-test shows a value of 8.76 with a p-value=0.00143 (p<0.005) which is highly significant. ◈ EPITHELIALISATION OF GRAFT: The two groups do not significantly differ in the epithelialisation of the recipient area in the follow-up period with the p value =0.65 which is not significant. CONCLUSION: Epidermal skin grafting has better donor site healing and no pain at donor site as compared to Split skin grafting. Epithelialisation of graft at recipient area does not significantly differ from Split skin graft. Hence Epidermal graft is a promising alternative to the more invasive conventional surgical techniques as it is day care surgery without anesthesia and reduces the surgical burden for patients in need of wound coverage.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221711059 |
| Uncontrolled Keywords: | Wounds, Epidermal Grafting, Split Skin Grafting. |
| Subjects: | Respiratory Medicine > General Surgery > Respiratory Medicine > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 09 Feb 2021 01:32 |
| Last Modified: | 02 Aug 2022 06:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13946 |
Actions (login required)
 |
View Item |
