Shyamsundar, R (2020) A Study on Local Injection of Methylprednisolone acetate to Prevent Seroma Formation after Mastectomy. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Seroma formation is a common problem in post-operative period, especially in patients undergoing mastectomy surgeries and they still remain a significant problem and pose challenges in management despite various advancements. One technique which has been suggested to reduce this Seroma formation is the installation of single dose injection of methylprednisoloneacetate in post-operative period. But still there is lack of enough evidence to consolidate this and bring it into regular practice. Hence there is a need for a well framed study to investigate various factors and add further evidence to strengthen the existing data. AIM & OBJECTIVES: To assess the variations in the following outcomes in patients presenting with Seroma formation after mastectomy with single dose of methylprednisoloneacetate given with those who were not given. MATERIALS & METHOD: STUDY CENTRE Institute of General Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai Duration of study January 2018 to May 2019 Study design Randomized Control Trail Sample size 40 Inclusion criteria 1. Age :18 - 70 years. 2. Female. 3. Primary breast cancer: mastectomy with sentinel node biopsy mastectomy with/without sentinel node biopsy and axillary node dissection. Exclusion criteria: 1. Patients of less than 18 years and more than 70 years. 2. Previous axillary surgery. 3. Recent treatment with systemic steroid 4. Allergy to trial drug. RESULTS: The study included 40 patients who were selected with inclusion and exclusion criteria. All patients were followed up and the following results were obtained. SEROMA FORMATION: Among the 40 patients, all the 40 patients were females, diagnosed as CARCINOMA BREAST and undergone MODIFIED RADICAL MASTECTOMY. Inj methylprednisolone acetate were given to 20 patients & not given for 20 patients. In the given 20 patients , Seroma formation was present for 11(55%) patients & not present for 9(45%) patients against those who were not given had Seroma formation for 18 (90%) & no Seroma formation for 2(10%)patients. Hence inj methylprednisoloacetate significantly reduces Seroma formation . p value was 0.015. CONCLUSION: Since Seroma formation is the most common complication of Mastectomy and among the methods used to reduce its incidence, steroid administration seems to be the most cost effective and shows promising results. In the study , the use of methylprednisoloneacetate which is both cost effective and reduces seroma formation compared to those patients who doesn't receive inj methylprednisoloneacetate. Its routine use in every case is recommended under good antibiotic cover and wound care. local injection of methyl prednisolone has no effect in preventing wound infection and wound dehiscence.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711018 |
| Uncontrolled Keywords: | Local Injection of Methylprednisolone acetate to Prevent Seroma Formation after Mastectomy |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 09 Feb 2021 00:45 |
| Last Modified: | 09 Feb 2021 00:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13935 |
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