A Study on Acute Adverse Effects of Blood Transfusion in a Tertiary Care Centre

Vijayakumar, P (2020) A Study on Acute Adverse Effects of Blood Transfusion in a Tertiary Care Centre. Masters thesis, The Tamilnadu Dr.M.G.R. Medical University, Chennai.


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OBJECTIVE: This study was designed to analyse the frequency of acute transfusion reactions and nature of transfusion reactions reported to the blood bank in the kilpauk medical college and hospital and the Department of Transfusion Medicine, Tamilnadu Dr M.G.R. Medical University, Chennai Materials and Methods: All acute transfusion reactions (ATRs) reported to the blood bank over a period of 12 months (May 2018 to April 2019) were reviewed and analyzed. The risk of transfusion reactions associated with each individual component was assessed. RESULTS: A total of 16592 units of whole blood and component transfusions were carried out of which a total of 46 (0.3%) ATRs were encountered. Packed red blood cells (PRBCs) (n = 38, P = 0.075) and whole blood (WB) (n = 4, P = 0.535) were most commonly implicated. FNHTR was the most frequent transfusion reaction encountered (72%), seen most commonly with PRBC (risk of 0.47%), and WB (risk of 0.12%,) transfusions. This was followed by allergic reaction reactions (24%), which were seen more commonly with PRBCs (risk of 0.13%,). No reactions were observed with cryoprecipitate. CONCLUSION: In our study, we observed acute transfusion reactions in 0.3% of transfusions with 54.5% definite attribution to the components transfused. The majority of the reactions observed were FNHTR and Allergic Transfusion Reactions. In the severity level most of the reactions were mild. Since transfusion reactions likely to happen even after several precautions, it is imperative to strengthen further the hemovigilance system for better outcome.

Item Type: Thesis (Masters)
Additional Information: 201731004
Uncontrolled Keywords: Acute Adverse Effects, Blood Transfusion, Tertiary Care Centre.
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 16:42
Last Modified: 05 Feb 2021 16:42
URI: http://repository-tnmgrmu.ac.in/id/eprint/13902

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