Evaluation of Corrected Count Increment in Hemato-Oncological Patients receiving Single Donor Platelets Transfusion

Senthil, E (2020) Evaluation of Corrected Count Increment in Hemato-Oncological Patients receiving Single Donor Platelets Transfusion. Masters thesis, The Tamilnadu Dr.M.G.R. Medical University, Chennai.


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BACKGROUND: Single donor platelet transfusion is an essential component of supportive therapy in patients with hemato-oncological patients. SDP transfusion is given either prophylactically to reduce the risk of bleeding or therapeutically to control active bleeding. Although many patients have an appropriate increase in platelet count when transfused with single donor platelets, less than adequate results tend to be seen in 15%-25% of the hemato-oncology patient. Unsatisfactory response to SDP transfusion is often multi-factorial, with 80% of refractoriness being predominantly due to nonimmune causes. AIM OF THE STUDY: The aim of the study was to evaluate the response to SDP transfusion by the calculation of Corrected Count Increment (CCI) in hemato-Oncological Patients after transfusion at specified time period. The study also tried to find out clinical factors associated with unsuccessful increment. MATERIALS & METHODS: The study was conducted over a period of one year (July 2018 to June 2019). In total, 85 hemato-oncological patient samples were tested for CCI at 1 and 24 hours after SDP transfusion. Descriptive statistical analysis was performed to calculate the percentage and mean count. RESULTS: The mean count of transfused platelets was 3.1 × 10¹¹ / unit. The mean platelet count before transfusion was 18.3 × 10³ / μL. The mean platelet increment at 1 hour was 24.7 10³ / μL and 24 hours was 13.04 × 10³ / μL. The mean CCI at 1 hour and 24 hours was 12875.49 and 6372.518 respectively. In total, 14 (16.4%) out of 85 patients received suboptimal dose of platelets, 7(8.2%) of the patients showed unsuccessful CCI at 24 hours despite successful CCI at 1 hour. All these 7 patients had clinical factors possibly responsible for failure of increment. However, in 7 (8.2%) of the remaining patients also had associated clinical factors despite successful CCI at 24 hours. 71 (83.6%) of the total 85 patients received optimal dose of platelets. Out of these 71 patients, 70 who had successful 1 hour CCI, 19 of these patients showed failure of expected CCI at 24 hours. The remaining one patient showed unsuccessful CCI after 1 hour of transfusion itself. CONCLUSION: In our study, almost 2/3rd of the hemato-oncological patients on chemotherapy showed successful CCI after 24 hours of SDP transfusion. The probable reason for unsuccessful CCI at 24 hours despite successful CCI at 1 hour after SDP transfusion is attributed to certain non-immunological clinical factors like fever, splenomegaly and sepsis. Further, the reason for unsuccessful CCI at 24 hours observed in few of our cases is suboptimal dose of platelets. However, it is imperative to conduct further study on larger number of cases to arrive at a definitive conclusion.

Item Type: Thesis (Masters)
Additional Information: 201731003
Uncontrolled Keywords: Single Donor Platelets (SDP), Corrected Count Increment (CCI), Clinical Factors, Hemato-oncological Patients.
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 16:33
Last Modified: 05 Feb 2021 16:33
URI: http://repository-tnmgrmu.ac.in/id/eprint/13900

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