Effect of Vitamin D Supplementation on the Severity of Atopic Dermatitis

Bede Anand, (2020) Effect of Vitamin D Supplementation on the Severity of Atopic Dermatitis. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.

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Abstract

BACKGROUND: Atopic dermatitis (AD) is an itchy chronic relapsing inflammatory skin condition that often starts in early childhood. Vitamin D is involved in important regulatory mechanisms of the innate and adaptive immune system. Vitamin D Receptor (VDR) has been found in keratinocytes and cells of immune system. Vitamin D supplementation has immunomodulatory effect and improves skin barrier function. Because of this action it has a marked reduction in severity of Atopic Dermatitis. AIM OF THE STUDY: To assess the effect of Vitamin D supplementation on the severity of Atopic Dermatitis. MATERIALS AND METHODS: A total of 25 patients with Atopic dermatitis who were on emollients and antihistamines only and not on systemic immunosuppressant for the past one month with vitamin D < 10 ng/ml were included in the study. Patients were supplemented with 60,000 U of vitamin D for 5 days followed by RDA dosage for 25 days. Severity was assessed by SCORAD before and after supplementing vitamin D. SCORAD is assessed by area of involvement, intensity of symptoms, subjective symptoms. RESULTS: Vitamin D supplementation has improved the severity of Atopic dermatitis by 73.2% (60.6% - 83.9%). CONCLUSION: Vitamin D can be a safe, easy, effective adjuvant treatment in atopic dermatitis of all age groups.

Item Type: Thesis (Masters)
Additional Information: 201730352
Uncontrolled Keywords: Atopic Dermatitis, SCORAD, Immunomodulation.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 15:42
Last Modified: 05 Feb 2021 15:42
URI: http://repository-tnmgrmu.ac.in/id/eprint/13893

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