A Cross sectional observational study on dermoscopic patterns in basal cell carcinoma at a tertiary hospital in South India

Diya Katrina Koikkara, (2020) A Cross sectional observational study on dermoscopic patterns in basal cell carcinoma at a tertiary hospital in South India. Masters thesis, Christian Medical College, Vellore.

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Abstract

INTRODUCTION: Basal cell carcinoma (BCC) is a non-melanoma skin cancer that is the most common cancer worldwide. There is little known about the clinicopathological profile of Indian patients with basal cell carcinoma. Dermoscopy is an invaluable tool in the diagnosis of basal cell carcinomas. The role of dermoscopy in the diagnosis of basal cell carcinoma in Indian population has not been previously studied. OBJECTIVES: 1. To describe the clinical and pathological profile of patients with basal cell carcinoma in the Indian skin type. 2. To describe the dermoscopic patterns seen in basal cell carcinoma. METHODS: We conducted a hospital based cross sectional observational study between November 2017 and April 2019. Fourty-four BCCs in 40 patients confirmed by histopathology were studied based on their clinical profile and dermoscopic patterns. RESULTS: Forty-four BCCs among 40 patients were recruited in our study. A majority of the patients were between 60-70 years and there was a male:female ratio of 1.35:1. The mean age of the study population was 59.7 ±2.04 years. All the BCCs were pigmented (n=44); with features of other clinical subtypes; pigmented nodular (n=28), pigmented superficial (n=15) and pigmented morpheaform (n=1). Majority of the BCCs (72.7%) were over photo-exposed sites. All the lesions showed asymmetry on dermoscopy in terms of pigmentation, morphological structures and vessels. Pigmented structures like maple leaf-like areas (86.7%, p=0.00), spoke wheel areas (26.7%, p=0.014) and brown dots (60%, p=0.03) were significantly associated with superficial BCCs. Arborizing vessels (57.1%, p=0.003%), micro-arborizing vessels (60.7%, p=0.006), out of focus arborizing vessels (84.6%, p=0.009) and out of focus short fine telangiectasias (38.5%, p=0.009) were significantly associated with nodular BCCs. Non-pigmented and non-vascular structures on dermoscopy including ulceration (71.4%, p=0.00), blue-white veil (89.3%, p=0.043), crust (82.1%, p=0.001) and hemorrhage (82.1%, p=0.00) were also significantly associated with nodular BCCs. Fourty-three of the 44 cases fulfilled Menzies criteria. CONCLUSION: Pigmented basal cell carcinomas are the most common of all subtypes in the Indian population.

Item Type: Thesis (Masters)
Additional Information: 201730302
Uncontrolled Keywords: Dermoscopic patterns, Basal Cell Carcinoma (BCC), tertiary hospital, South India.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 15:10
Last Modified: 05 Feb 2021 15:10
URI: http://repository-tnmgrmu.ac.in/id/eprint/13889

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