A Prospective study on Leprosy Reactions and Its risk factors

Lakshmanan, C (2020) A Prospective study on Leprosy Reactions and Its risk factors. Masters thesis, Chengalpattu Medical College and Hospital, Chengalpattu.


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BACKGROUND: Leprosy reactions are immunological phenomenon which can occur before, during or after the completion of Anti-Leprosy therapy. They contribute enormously to the burden of leprosy and need to be diagnosed and treated early, so as to prevent permanent nerve function impairment and disability. AIM OF THE STUDY: To determine the demographic details, risk factors, different clinical patterns, systemic complications, and histopathological correlation of Leprosy reactions METHODS: 100 Leprosy reaction patients during 18 months were included in the study and details pertaining to demographic profile, time of starting of MB-MDT, regimen taken and time of stopping MB-MDT, risk factors , cutaneous and extra cutaneous features, new disabilities , bacteriological index and histopathological reports were collected. They were treated and followed up for recurrence, complications and treatment response. RESULTS: Out of 100 patients, 64 had Type I reaction and 36 had Type II reaction. The mean ages of patients presented with Type I and Type II Leprosy reactions were 38.7 yrs and 48.17 yrs respectively. The most consistent risk factors in type I Leprosy reactions were Borderline Tuberculoid spectrum (75%), Anti-Leprosy drugs (42.1%) whereas in type II Leprosy reaction the major risk factors were higher Bacteriological Index (91.9%), Lepromatous (33.3%) and Borderline Lepromatous spectrum (63.8%). CONCLUSION: The risk factors were statistically significant and so patients should be properly counseled while starting on MDT and should always be co-administered with systemic steroids in high risk cases to prevent emergence of reactions. Most of the patients developed reactions de novo shows the need to improve surveillance for early detection and timely treatment of the disease as it affects both the individual and the society in the view of its communicability.

Item Type: Thesis (Masters)
Additional Information: 201730153
Uncontrolled Keywords: Leprosy Reactions, risk factors, Prospective study.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 02:47
Last Modified: 05 Feb 2021 02:47
URI: http://repository-tnmgrmu.ac.in/id/eprint/13877

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