A Study on Cutaneous adverse Drug Reactions to Imatinib

Saranya, S (2020) A Study on Cutaneous adverse Drug Reactions to Imatinib. Masters thesis, Madurai Medical College, Madurai.


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INTRODUCTION: An adverse drug reaction is defined by World health organization as "Any response to the drug which is noxious, unintended and occurs at doses used in man for prophylaxis, diagnosis or therapy". An adverse cutaneous reaction caused by drug is any undesirable change in skin, its appendages or mucous membrane and it encompass all adverse effects related to drug eruption, regardless of etiology. The pattern of adverse cutaneous reactions to drugs keep changing every year in accordance to emergence of newer drugs. There is a wide spectrum of cutaneous adverse drug reactions varying from transient maculopapular rash to fatal toxic epidermal necrolysis (TEN) reported with imatinib. Hence the aim of my study is to evaluate the clinical spectrum of Cutaneous Adverse Reactions (CADRs) due to imatinib in our population. AIM OF THE STUDY: To evaluate the pattern of cutaneous adverse reactions occurring in chronic myeloid leukemia and gastro intestinal stromal tumor patients on imatinib mesylate. MATERIALS AND METHODS: This study was conducted in department of medical oncology, Government Rajaji Hospital, Madurai Medical College, Madurai All confirmed cases on Imatinib were enrolled in the study over a period of 7 months after obtaining clearance from institutional ethical committee. All cases of Chronic Myeloid Leukemia and Gastrointestinal tumour patients on Imatinib attending oncology OPD irrespective of age and sex were included in the study. RESULTS: The commonest CADRs in our study is hypopigmentation which is seen in 23 patients (16.22%) followed by Melasma like pigmentation was noted in 21 patients (14.81%). CADRs were more commonly reported in the age group of 41 to 60 years. CONCLUSION: Melasma like pigmentation was noted in 21 patients (14.81%). Dermal type of melasma were noted in all patients. Woods lamp showed enhancement of pigmentation. ◈ Hair changes and mucosal changes were not seen in our study. ◈ Life threatening cutaneous reactions like DRESS, SJS, TEN were not seen in our study. ◈ Other side effects like psoriasis, pityriasis rosea, acneiform eruption, photosensitivity, erythema nodosum, sweets syndrome was not encounter in our study. ◈ Hence long term follow up will be needed to find out the course of skin changes which occured due to Imatinib and also to find out long term complications.

Item Type: Thesis (Masters)
Additional Information: 201730103
Uncontrolled Keywords: Cutaneous adverse Drug Reactions, Imatinib.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 02:31
Last Modified: 05 Feb 2021 02:31
URI: http://repository-tnmgrmu.ac.in/id/eprint/13873

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