Senthil Kumar, R P (2014) Outcome of cadaveric Renal Transplantation : Single centre experience. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION : T h e biggest medical breakthroughs of this century are transplantation of human organs. The escalating End stage Renal Disease population and the lack of suitable donors – this discrepancy is well known. The first deceased donor renal transplantation in our hospital was performed in the year 1996 with 73 deceased donor transplantations performed thereafter. T h ough deceased donor transplantation was started in the year 1996, it started gathering momentum only after the year 2008, when a doctor couple donated their brain-dead son’s organ, which gained widespread public attention. T he rate of deceased donors per million in India is far behind the world average rate. When compared with other countries like United States, Portugal and Spain the renal transplantation rate in India with a population of about 1.3 billion is only 3.2 per million population. T h e major cause of End Stage Renal Disease are Diabetes and Hypertension which is on the increase. The age-adjusted incidence of end stage renal disease is estimated to be 232 per million population. The only hope for patients with ESRD is renal transplantation, as the dialysis centres are limited to certain regions especially they are concentrated in the urban cities and is also expensive in the long run. The importance of this scenario is exemplified by this. The only way to combat the commercial organ transplantation is to increase the deceased donor transplantation. It also reduces the burden on the live related renal transplantation. Until a decade ago there was a lack of knowledge among the general public about deceased organ donation. But the crucial role played by the non governmental organization and media in support by the government implemented the deceased donor programme in the state of Tamilnadu successfully. AIMS : 1. To analyse the various donor and recipient Characteristics. 2. To analyse the post transplant infections and Post operative complications 3. To analyse the infection rates and acute Rejection rates with the use of induction Immunosuppression. 4. To analyse the patient survial rates. 5. To analyse the graft survival rates. CONCLUSIONS : The survival rates for both patient and graft of deceased donor transplantation is equal to that of live related renal transplantation. Out of 73 deceased donor transplantations, 28 (38.4 %) patients died. The causes of death were Sepsis and Delayed Graft Function - 20, Pneumonitis – 7, HCV related Decompensated liver disease -1. Only way to combat the illicit organ trading (commercial renal transplantation ) is deceased donor transplantation. Cadaver organs should be considered as nation’s resource and organs wasted should be treated as lives lost. Our deceased donor program demonstrates that it can be implemented successfully as long as the framework of the program maintains transparency and adheres to established protocols. Hence deceased donor transplantation is the need of the hour, which can be promoted by positive public attitude, identification of early brain death and certification, getting prompt consent for organ donation and adequate hospital infrastructure are essential prerequisites for successful organ transplantation. The state of TamilNadu would definitely be a good role model in this regard.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | cadaveric ; renal transplantation ; single centre experience. |
| Subjects: | MEDICAL > Nephrology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 11 Jul 2017 06:26 |
| Last Modified: | 11 Jul 2017 06:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1387 |
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