Analytical Cross Sectional study of Peripheral Nerve Damage in Leprosy by High Resolution Ultrasonography

Arun, P (2020) Analytical Cross Sectional study of Peripheral Nerve Damage in Leprosy by High Resolution Ultrasonography. Masters thesis, Stanley Medical College, Chennai.


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BACKGROUND: Ultrasonography(USG) is now being used worldwide for the identification of structural changes of peripheral nerves. To assess the involvement of peripheral nerves in leprosy, clinical assessment by palpation alone has an inherent limitation of being highly sensitive. It is easier to follow peripheral nerve along its superficial course for identification of pathology by high resolution ultrasonography. High resolution ultrasound is more economical and easier when compared to MRI. AIM OF THE STUDY: To evaluate the diagnostic value of high resolution ultrasonography and coloured Doppler in peripheral nerve trunks of leprosy patients. Study Design: Hospital based analytical cross sectional study in 60 new leprosy patients. MATERIALS AND METHODS: Sixty Newly detected Hansen cases fulfilling the criteria were included. Detailed history and examination with particular reference to peripheral nerve thickening were documented. All patients were subjective USG and Cross sectional area, echogenicity, and endoneurial blood flow of bilateral ulnar, median, lateral popliteal and posterior tibial nerves were recorded. Clinical and USG findings were correlated and analysed RESULTS: Significant correlation was observed between clinical parameters of grade of thickening, sensory loss and muscle weakness and ultrasound abnormalities of nerve endoneurial blood flow and cross sectional area. There was no significant correlation obtained between echogenicity and clinical nerve thickening. Nerve thickening was best picked up in ulnar nerve followed by common peroneal nerve and posterior tibial nerve. Demonstration of median nerve by ultrasonography was relatively difficult when compared to others. CONCLUSION: The clinical examination of enlarged nerves in leprosy is subjective and inaccurate. USG is the reliable method to find the hidden nerve damage which cannot be clinically appreciable.

Item Type: Thesis (Masters)
Additional Information: 201730051
Uncontrolled Keywords: Peripheral Nerve Damage, Leprosy, High Resolution Ultrasonography, Analytical Cross Sectional study.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 01:39
Last Modified: 05 Feb 2021 01:39

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