Comparison of Efficacy of Various Modalities of Treatment in Patients with Androgenetic Alopecia

Raju, P (2020) Comparison of Efficacy of Various Modalities of Treatment in Patients with Androgenetic Alopecia. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND AND OBJECTIVES: The most common cause of alopecia in males is due to androgenetic alopecia. It is due to a combination of genetic factors and the effect of androgens. The prevalence of androgenetic alopecia had been increasing gradually over the years and is characterized by patterned progressive hair loss. There are various modalities of treatment available such as topical minoxidil, topical finasteride, oral finasteride and the emerging methods such as PRP therapy. This study aims to compare the efficacy of topical 5% minoxidil along with minoxidil mesotherapy and the therapy with PRP microneedling as a monotherpy in the treatment of androgenetic alopecia. METHODOLOGY: This is a randomized clinical trial conducted from February 2018 to January 2019 at the department of dermatology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai. INCLUSION CRITERIA: 1. Male patients with Androgenetic alopecia attending outpatient clinic of Department of Dermatology, Madras Medical College & Rajiv Gandhi Government General Hospital. 2. Patients willing for study and regular follow up. 3. Age group of patients between 20 years and 50 years of age. 4. Patients with androgenetic alopecia stage Ⅱ-Ⅴ of Hamilton norwood classification EXCLUSION CRITERIA: 1. Patient not willing for study. 2. Patients with alopecia due to other causes such as telogen effluvium, anagen effluvium, alopecia areata, alopecia totalis. 3. Patients with uncontrolled diabetes, collagen vascular diseases, serious medical disorders (cardiac, renal, hepatic illness, severely immunocompromised, epilepsy). 4. Patients with history of keloids. 5. Patients having unrealistic expectations. 6. Patients having bleeding diasthesis history. Eighty male patients who satisfied the above criteria were included in the study. Patients were randomly allotted to two different groups by randomization software after written and informed consent given by patients .The two groups are Ⅰ. Topical 5% Minoxidil application twice daily with 5% minoxidil mesotherapy once a month for 6 months. Ⅱ.Platelet rich plasma application after microneedling over the areas of alopecia once a month for six months. RESULTS: The most common age group in this study was 21-30 years. The mean age in this study was 27.9 years. The average duration of disease in this study was 39.15 months. Family history of androgenetic alopecia was present in 48.8% of patients. The common stage of AGA was stage3 which constitutes about 45%. There was no significant improvement at the end of 3 months of treatment in both groups. There was a statistically significant difference in the treatment response at the end of 6 months of treatment with group 1 showing better response than group 2. CONCLUSION: PRP microneedling treatment once a month as a single modality of treatment in patients with AGA was not as effective when compared to 5% Minoxidil daily application with once a month 5% Minoxidil mesotherapy.It suggests that PRP if used as used a single modality of treatment will not be effective and it has to be combined with either topical minoxidil or oral finasteride.

Item Type: Thesis (Masters)
Additional Information: 201730007
Uncontrolled Keywords: Androgenetic alopecia, 5% minoxidil, Platelet rich plasma, microneedling.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Feb 2021 01:27
Last Modified: 05 Feb 2021 01:27

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