Comparative study of Clinico-Bacterio-Radiological Profile and Treatment Outcome of Smokers and Nonsmokers Suffering from Pulmonary Tuberculosis

Vijayaraj, R (2020) Comparative study of Clinico-Bacterio-Radiological Profile and Treatment Outcome of Smokers and Nonsmokers Suffering from Pulmonary Tuberculosis. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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INTRODUCTION: Tobacco smoking and tuberculosis are two major worldwide public health problems. Smoking increases the risk of contracting tuberculosis (TB), increases the risk of recurrent TB and impairs the response to treatment of the disease. This study is intended to explore the relationship in India. OBJECTIVES: To compare the clinical /bacteriological/radiological profile and treatment outcome between smoker and non-smoker suffering from pulmonary tuberculosis. METHODOLOGY: This is a Prospective /observational study was carried out in total of 100 patients attending the outpatient clinic or being admitted as inpatient of the Department of Respiratory Medicine, Tirunelveli Medical College Hospital, Tirunelveli. After collecting the smoking history, sputum AFB and clinical history and examination findings were noted. Patient were followed up for treatment outcomes and sputum conversion. RESULTS: Majority (46%) of the study population were belonging to 41-60 age category. Out of the study population, majority were males, 67 (67%) majority were Non-smoker (52). Among the smokers, 16 were Ex-smoker and 32 were Smokers. Of the smokers, 13 were smoking cigarettes and 35 were smoking beedi. The mean Smoking Index of the study population is 428.58 with the standard deviation of 215.35. All the 100 were presented with cough with expectoration, 78 with Breathlessness, 11 with chest pain, 12 with Haemoptysis, 93 with fever and 88 with loss of appetite. Majority (38) were having 1+ bacteriological grade in sputum AFB. 4 were having 1+ bacteriological grade in sputum AFB during their completion of intensive phase. All were 100% sensitive in CBNAAT test. In the study population, 73 were declared cure at the end of the treatment period, 24 of them fall under completed category, 3 become defaulter. When smoking status was compared with the clinical symptoms such as Cough with Expectoration, Chest pain, Haemoptysis, Fever and Loss of Appetite, there is no statistical significance. Breathlessness was significantly more in smokers with the p-value of 0.016. When Sputum, Cavity, Outcome and severity with Smoking status, there was no association between sputum grading and smoking status. The mean smoking index among completed group and cured group are not statistically significant with 464.1176 and 387.5714 respectively. CONCLUSION: Cavitation was more among smokers, More number of advanced severity cases were present in smokers and more number of defaulters and less number of cured in smokers were present with a statistically significant with p-value less than 0.05. Smoking cessation programmes need to be targeted at tuberculosis patients both by clinicians specializing in tuberculosis and by national tuberculosis control initiatives. The effectiveness of such programmes in reducing smoking among tuberculosis patients and improving tuberculosis treatment outcomes also need to be assessed.

Item Type: Thesis (Masters)
Additional Information: 201727204
Uncontrolled Keywords: Clinico-Bacterio-Radiological Profile, Treatment Outcome of Smokers and Nonsmokers Suffering, Pulmonary Tuberculosis, Comparative study.
Subjects: MEDICAL > Tuberculosis and Respiratory Medicine
Depositing User: Subramani R
Date Deposited: 04 Feb 2021 16:35
Last Modified: 04 Feb 2021 16:35

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