Ramasamy, A (2020) To Evaluate the Markers (Microalbuminuria, Serum Albumin , pCO2) in patients with COPD and COR Pulmonale and the effect of therapeutic measures on these markers. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION: COPD is a heterogenous disease with both pulmonary and extra pulmonary symptoms characterized by long-term airflow obstruction. Cor pulmonale in COPD results in increased morbidity and mortality and constitutes a tremendous socioeconomic burden. Various studies shows microalbuminuria, serum albumin, pCO2 as a novel cardiovascular biomarker in patients with COPD. Current study is intended to carry out with the objective to find the prevalence and relationship of microalbuminuria, serum albumin, pCO2 in COPD and Cor Pulmonale patients and the effect of therapeutic measures on these markers. OBJECTIVES: The main objective of this study is to find the prevalence and relationship of microalbuminuria, serum albumin and pCO2 with clinical and physiological parameters in COPD and Cor Pulmonale patients and the effect of therapeutic measures on these markers. METHODOLOGY: This is a Prospective observational study done among patients attending Thoracic Medicine department at GHTM, Tambaram Sanitorium and Stanley Medical College during June 2018– May 2019. This study included 82 subjects. COPD diagnosis and staging was done according to GOLD criteria. 2-D ECHO with colour doppler of the heart, BMI, smoking index, microalbuminuria, serum albumin, pCO2 were measured in all subjects at baseline and after 6 months of therapeutic intervention as per GOLD guidelines. Data were analysed using SPSS software version 16. RESULTS: Microalbuminuria was significantly associated with age, BMI, Smoking Index, GOLD severity staging and acute exacerbations. Microalbuminuria was not significantly associated with gender. Serum Albumin and pCO2 was not associated with Smoking Index, but associated with GOLD severity staging and acute exacerbations. No significant change in microalbuminuria after therapeutic intervention, but serum albumin, pCO2 showed significant change in stable COPD and Cor Pulmonale after therapeutic intervention. CONCLUSION: The determination of microalbuminuria, pCO2, serum albumin is simple and inexpensive. These markers can serve to diagnose Cor Pulmonale early in COPD patients in resource limited and emergency setting. Serum albumin and pCO2 may serve as a tool for monitoring the therapeutic intervention. This study suggests that endothelial and microvascular mechanisms are promising targets for early detection of Cor Pulmonale prevention and management.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201727055 |
| Uncontrolled Keywords: | COPD, Cor Pulmonale, microalbuminuria, serum albumin, pCO2. |
| Subjects: | MEDICAL > Tuberculosis and Respiratory Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 04 Feb 2021 16:10 |
| Last Modified: | 04 Feb 2021 16:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13808 |
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