Stephen Varghese, Samuel (2020) Outcomes in elderly patients admitted with sepsis in a tertiary care hospital: A Follow up Observational study. Masters thesis, Christian Medical College, Vellore.
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Abstract
PURPOSE: Factors predicting the outcome of sepsis in older patients remains unclear, especially in Indian context. We assessed the outcomes in older adults patients admitted with sepsis in a tertiary care hospital in South India. AIM OF THE STUDY: To determine the outcomes of sepsis in older adults admitted to a tertiary care centre in India. OBJECTIVES: 1. To determine the outcomes of sepsis in older adults admitted to a tertiary care centre in India 2. To determine the risk factors in elderly contributing to mortality in patient admitted with sepsis. 3. Effect on activities of daily living following sepsis. 4. To sensitize doctors about antibiotic stewardship in the elderly. METHODS: Prospective observational study. Various factors contributing to outcomes in patients admitted with sepsis were documented. RESULTS: Among 201 hospital admissions with sepsis between March 2018 and September 2019, the overall mortality rate was 36.32% with mean duration of hospital stay of 12.9 days. A higher mortality was noted in patients with a longer duration of ventilation (OR 0.6 CI 0.53-0.87, p value 0.003), longer length of ICU stay (OR 1.1 CI 1.05-1.36, p value 0.006) and in patients on vasoactive supports (OR 26.4, 95% CI 6.13-114.4, p-value < 0.001). Higher SOFA and APACHE II scores were not found to be associated with mortality. The Barthel Index worsened after sepsis (< 0.001). The most widely used empirically antimicrobial group was the Penicillin group, followed by Carbapenems. CONCLUSIONS: The mortality rate of older patients admitted with sepsis was 36.32%. As SOFA and APACHE II scores did not correlate with increase in mortality, the search for a more robust sepsis severity scoring system in the older person is the need of the hour.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 201726053 |
| Uncontrolled Keywords: | Sepsis, Infection, elderly, older adults, antibiotics. |
| Subjects: | MEDICAL > Geriatrics |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Feb 2021 17:07 |
| Last Modified: | 03 Feb 2021 17:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13800 |
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