Shankar, P (2013) Epidemiological profile, clinico-pathological correlation and treatment response in Adult patients with IgA nephropathy. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION : First described by Jean Berger as a disease entity with diffuse mesangial deposition of IgA deposits. Once thought to have benign entity of self limiting hematuria, now found to have slowly progressive in nature with the propensity to develope chronic kidney disease in 15-20 percent in 15 -20 years. It presents with constellation of clinical syndrome ranging from asymptomatic urine abnormalities to smoldering rapidly progressive glomerulo nephritis. Diversity of clinical signs and syndrome is a constant feature. With the advance in genetic, more molecular pathways are unraveled, pathogenesis were defined little better than previous, so this commonest glomerulonephritis is revealing its secrets. Better understanding of glycation, galactosylation molecular machineries in depth of enzymes and chaperone, better search of happenings of talks of mesangium, podocytes and proximal tubule through cytokines and receptors, better knowledge of mucosa marrow axis and TLR clearly will open new prospective in treatment. Epidemiological point of view, both increasing awareness such as treatment of for hematuria, prompt referral to the nephrologist, more precise immunoflourescence studies, IgA nephropathy incidence is on increasing trend . Hence proper, long term randomized control trials(RCT) needed in many areas of IgA nephropathy. AIM OF THE STUDY : 1. To study the epidemiological profile of IgA nephropathy in adult patients. 2. To study the clinicopathological correlation of IgA nephropathy. 3. To evaluate the response to treatment, predictors of response and Risk factors in the progression to CKD in these patients. CONCLUSION : 1. Nephrotic syndrome is the most common clinical presentation in IgA nephropathy. 2. Majority of the patients presented with renal failure at entry into study. 3. Severe MEST scoring was significantly associated with renal failure at presentation. 4. Non- responders of proteinuria and those who had severe S and T scores in MEST scoring system progressed to chronic kidney disease. 5. Those who had either complete or partial remission of proteinuria had less chance to progression of CKD during the follow up period.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Epidemiological profile ; clinico-pathological correlation ; treatment response ; adult patients ; IgA ; nephropathy. |
| Subjects: | MEDICAL > Nephrology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 11 Jul 2017 05:16 |
| Last Modified: | 11 Jul 2017 05:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1377 |
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