Dania Tamilselvi, T (2020) A Study of Association of High Serum Prolactin Levels with other Biochemical Parameters in Pre Eclampsia. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
INTRODUCTION: Pre eclampsia is a pregnancy related disorder, which is the leading cause of maternal and fetal mortality and morbidity. It clinically manifest after 20 weeks of gestational age with blood pressure > 140/90 mm of Hg and proteinuria and resolves within 42 days after delivery. It is widely known as the “Disease of theories” as its exact etiopathogenesis is still an enigma. Among the various hypotheses, an imbalance between angiogenic and antiangiogenic property are discussed widely. At this point, the role of prolactin hormone is widely researched. In pre eclampsia, there is upregulation of trophoblastic cathepsin D, which cleaves 23 KDa prolactin into its fragments namely 14 KDa and 16 KDa. This 16 KDa fragment typically exhibits anti angiogenic properties by blocking vascular endothelial growth factor and placental growth factor. AIM OF THE STUDY: To find the roleof serum prolactin and other biochemical parameters such as serum uric acid, lactate dehydrogenase, alkaline phosphatase and 24 hours urine protein in preeclampsia. OBJECTIVES: 1. To estimate the level of serum prolactin, serum uric acid, serum lactate dehydrogenase, serum alkaline phosphatase and 24 hours urine protein in Preeclampsia patients. 2. To evaluate the correlation of elevated levels of serum Prolactin and other biochemical parameters in preeclampsia patients in a tertiary care center. MATERIALS AND METHODS: It is a case control study, conducted in the department of biochemistry, government Coimbatore medical college during the period of march 2018 to march 2019 among 100 antenatal mothers(50 pre eclampsia mothers and 50 normal antenatal mothers). Statistical analysis is done using chi-square test and student’s t-test. OBSERVATIONS AND RESULTS: Among the 50 Pre eclampsia mothers studied, the mean serum prolactin is 1223.45 ng/ml against 12.05 ng/ml in controls, the mean serum lactate dehydrogenase in pre eclampsia is 654.64 IU/L against 243.36 IU/L in normal antenatal mothers. The following parameters like serum prolactin, serum lactate dehydrogenase, serum alkaline phosphatase, 24 hours urine protein are statistically significant as their p value is < 0.05. In this study, Receiver operating characteristic curve of Serum Prolactin has criterion > 147.7 ng/ml as the cut off value for predictingpre eclampsia with sensitivity- 98 % and specificity- 100%. For Serum Lactate Dehydrogenase, Receiver operating characteristic curve has criterion >379.9 IU/L as the cut off value for predicting pre eclampsia with sensitivity- 98 % and specificity- 98%. For Serum Alkaline Phosphatase, Receiver operating characteristic curve has criterion >95 IU/L as the cut off value for predicting pre eclampsia with sensitivity- 92% and specificity- 96%. For Serum Uric Acid, Receiver operating characteristic curve has criterion >4.85 mg/dl as the cut off value for predicting pre eclampsia with sensitivity- 92% and specificity- 96%. CONCLUSION: Pre eclampsia is the leading cause of fetal and maternal morbidity and mortality.To prevent the complications, it is necessary to subclassify pre eclampsia based on biomarkers. Several research activities have analysed different biomarkers in this area of expertise. In this study, among the commonly available biochemical parameters, there is significant association between pre eclampsia and serum prolactin, serum uric acid, serum lactate dehydrogenase and 24 hours urine protein.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201723651 |
| Uncontrolled Keywords: | Pre eclampsia, vascular mimicry, disease of theories, serum prolactin, oxidative stress, biomarkers, trophoblast, placenta, vascular endothelial growth factor, placental growth factor, HELLP syndrome, pregnancy, mortality, morbidity. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Feb 2021 02:44 |
| Last Modified: | 03 Feb 2021 02:44 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13761 |
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