A Toxicity study on Kantha Chendrum

Benitta, K (2008) A Toxicity study on Kantha Chendrum. Masters thesis, Govt. Siddha Medical College, Palayamkottai.

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Abstract

INTRODUCTION : Nature and human beings are the wonderful creation of God. Pray and thank the god for creating nature, lands, water, air, resources, rain etc for living being for their better survival. It is the ultimate duty of the human beings, to protect the nature and live in harmony with nature. AIM AND OBJECTIVES : Kantha chenduram is the drug of choice for pandu and sobai caused by various etiologies. Nowadays many people are suffering from pandu and sobai. Kantha chenduram is widely used in general practice by siddha physicians. So, to access its safety, the author has selected this drug for toxicological study. The main aim of this study is to evaluate the toxic effect of Kantha chenduram on albino rats under varying conditions of drug administration. The studies include the following : • Acute toxicity study • Chronic toxicity study • Haematological Investigations and Biochemical analysis of medicine Kantha chenduram. • Histopathological study of the organs such as kidney, heart, and liver in albino rats. CONCLUSION : From the studies conducted we come to know that Kantha Chenduram did not produce death in rats with in 24 hours at the dose level of 1600 mg / 100 g body weight of the animal. The chronic toxicity studies also revealed that the drug has harmful effect on liver kidney and heart in long term administration. The dose administered for chronic toxicity studies in rats are relatively very high, compared to the dose administered to the patients. The aim of giving such a high dose was to find out the type of toxicity produced by it. This toxicity could occur in patient if the prescribed dose is not advised by the physician or not followed by the patient. Further studies with smaller doses may perhaps establish the safety of the drug. In clinical practice, the drug Kantha Chenduram should be used with caution. The patient must be advised by the physician to follow correct dose (marunthalavu), course of treatment (naal alavu), adjuvant (anupanam) and diet restrictions (pathiyam).The physician should regularly monitor the patient by doing haematological examination and also the liver and kidney and the cardiac function tests.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Toxicity study ; Kantha Chendrum.
Subjects: AYUSH > Nanju Noolum Maruthuva Neethi Noolum
Depositing User: Kambaraman B
Date Deposited: 11 Jul 2017 03:54
Last Modified: 29 Dec 2018 17:03
URI: http://repository-tnmgrmu.ac.in/id/eprint/1366

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