Sivakumar, K G (2007) Post Transplant Nephrotic syndrome - Clinicopathological profile and it's out come. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND : Among the various factors that can affect the renal graft function, proteinuria of more than 1gm per day is one of the important factors in predicting graft outcome. Nephrotic range proteinuria is known to portend an even worse prognosis characterized by a markedly decreased graft survival rate. As per the previous data, 1 and 5 years graft survival of patients with Post Transplant Nephrotic syndrome (PTNS) were 75.3% and 37.5%, respectively when compared with 87.5% and 52.5% for those without proteinuria. Most of these data were studied before the usage of newer immunosuppression ans newer biopsy criteria. three major studies involving PTNS were conducted prior 1990. many data like predisposing factors, etiology and clinical course are unclear. There are no Indian studies in this regard. AIM OF THE STUDY : 1. To determine the incidence of proteinuria (PTNS). 2. To eva1uate the renal graft histo1ogica1 patterns associated with PYNS. 3.To determine the effect of various causes of PYNS, on the graft surviva1 outcome. 4.To ana1yze the predictors of graft outcome, among the PYNS subgroups. CONCLUSIONS : 1. The incidence of PYNS was 10.2%. 2. PYNS occurred at a mean duration of 20 months Jo11owing transµ1ant. 3. CAN was the commonest cause of PYNS. 4. IgA nephropathy was the commonest cause of PYNS among the recurrent or de novo CN group. 5. TSCS occurred earliest and had poorer outcome among the recurrent or de novo CN group. 6. Craft loss occurred in one third of the patients with PYNS. 7. Craft loss was more common in recurrent or de novo CN group when compared to CAN group.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Post Transplant Nephrotic syndrome ; Clinicopathological profile. |
| Subjects: | MEDICAL > Nephrology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 11 Jul 2017 03:44 |
| Last Modified: | 11 Jul 2017 03:44 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1364 |
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