Visual Evoked Potential and Visual Reaction Time in Newly Diagnosed Hypothyroid Females Before and After Treatment and Its Correlation with TSH Levels and BMI

Kavitha, K V (2020) Visual Evoked Potential and Visual Reaction Time in Newly Diagnosed Hypothyroid Females Before and After Treatment and Its Correlation with TSH Levels and BMI. Masters thesis, Coimbatore Medical College, Coimbatore.

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Abstract

BACKGROUND: Dysfunction of the central nervous system (CNS) is an important consequence of thyroid hormone deficiency. Evoked potentials like visual evoked potentials (VEP) and visual reaction time (VRT) were provide a reliable and objective measure of function in related sensory system and tracts. Visual evoked potential (VEP) measures the time taken for visual stimulus to travel from the eye to the occipital cortex. Hypothyroidism affects the central nervous system (CNS) through its role in gene expression, myelin production, axonal transportation, and neurotransmitters. Reaction time is the time interval between onset of stimulus and occurrence of response. Normal thyroid functions are essential to the attentiveness and alertness. The patients suffering from the thyroid disease have an altered in the conduction of impulses results in abnormal VEP and VRT. AIM OF THE STUDY: The aim of this study was to assess the visual evoked potential (VEP) and visual reaction time (VRT) in newly diagnosed hypothyroidism females before and after treatment. MATERIALS AND METHODS: Sixty newly diagnosed hypothyroid females in the age group of 18-50 years as the study group ABT (Before treatment) and group AAT (after treatment), using RMS EMG EP MKII, version: 7.5.11 system- to collect, analyze, print and store a visual evoked potential data and using Inquisit 5.0 version software recording Simple visual reaction time. The parameters were compared and correlated among hypothyroid female individuals before and after therapy with L-thyroxine by using paired 't’ test and Pearson’s correlation tests. RESULTS: There is significant negative correlation of the delay in the latency of N75, P100, N145 with T3 levels and positive correlation with TSH levels and positive correlation of reduced amplitude of N75-P100 with T3 and negative correlation with TSH levels. There was delayed visual reaction time in hypothyroid individuals were become normal in VRT after proper treatment. CONCLUSION: The results of this study concludes that delay in P100, N75 and reduced PN75-P100 amplitude of visual evoked potential and increased visual reaction time in hypothyroid patients was are reversible after three months of proper treatment with L thyroxine.

Item Type: Thesis (Masters)
Additional Information: 201715252
Uncontrolled Keywords: Visual Evoked Potential, Evoked Potentials, Visual Reaction Time, Hypothyroid.
Subjects: MEDICAL > Physiology
Depositing User: Subramani R
Date Deposited: 30 Jan 2021 17:04
Last Modified: 01 Mar 2021 02:50
URI: http://repository-tnmgrmu.ac.in/id/eprint/13496

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