Left Ventricular Hemodynamics and Electrophysiology in Obese Young Adult Males

Sathishkumar, S (2020) Left Ventricular Hemodynamics and Electrophysiology in Obese Young Adult Males. Masters thesis, Stanley Medical College, Chennai.

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Abstract

BACKGROUND: Obesity means abnormal or excessive fat accumulation in the body that presents a risk to health. Obesity results from an energy imbalance between calorie intake and physical activity. In India, the prevalence of overweight and obese adults was 11% and 2% respectively. Obesity can be seen as the first wave of a defined group of Non-Communicable Diseases (NCDs) called “New World Syndrome,” creating an enormous socioeconomic and public health burden. AIM OF THE STUDY: To study the early alterations in the left ventricular structure and cardiovascular autonomic changes in obese young adult males and compare it with overweight and normal individuals. OBJECTIVES: 1. To assess the left ventricular hemodynamic changes in obese young adult males using echocardiogram. 2. To study the electrophysiology of heart in obese young adult males using heart rate variability analyzer. 3. To correlate total cholesterol value with left ventricular hemodynamic and electrophysiological changes in obese young adult males. MATERIALS AND METHODS: The study population was 30 obese, 30 overweight and 30 normal-weight individuals of age group (18-38yrs). They were subjected to BMI, blood pressure, heart rate, waist circumference, hip circumference, waist-hip ratio, left ventricular mass (LVM), LVM indexed to height, low-frequency power in a normalized unit, high-frequency power in a normalized unit, LF/HF ratio and serum total cholesterol level estimation. The data obtained were analyzed using SPSS software version 20. ANOVA and Post hoc tests were chosen to find out the significant difference. A Pearson correlation test was carried out to find the correlation between the parameters. RESULTS: BMI, waist circumference, hip circumference, waist-hip ratio, blood pressure, heart rate, LVM, LF norm, HF norm, LF/HF ratio and total cholesterol level were found to be more among the study participants in the obese group followed by the overweight and normal groups with a P-value < 0.05. All three groups were found to have a similar mean when LVM/Height2.7 was considered with a P-value > 0.05. There was a positive correlation between LVM/Height2.7 and total cholesterol in obese and overweight groups. There was a positive correlation between the LF/HF ratio and total cholesterol in obese and normal groups. CONCLUSION: All three, waist circumference, hip circumference and waist-hip ratio can act as a proxy for obesity, similar to body mass index. Increased blood pressure, heart rate, left ventricular mass and total cholesterol levels indicating weight gain is a potential risk factor for NCDs. So our future studies should be a cohort aimed at analyzing the reversibility of the cardiovascular changes on weight reduction so that we can reduce the morbidity and mortality due to obesity. We should make initiatives aiming at primary prevention along with early detection of cardiovascular changes to ensure a healthy future for the upcoming generations.

Item Type: Thesis (Masters)
Additional Information: 201715052
Uncontrolled Keywords: Heart Rate Variability, Left Ventricular Mass, Obesity, Total Cholesterol.
Subjects: MEDICAL > Physiology
Depositing User: Subramani R
Date Deposited: 30 Jan 2021 16:48
Last Modified: 01 Mar 2021 03:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/13487

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