Evaluate Cognitive Evoked Potential and Serum Adiponectin Level in Prediabetes: A Cross Sectional study

Leela Priyadharsini, B (2020) Evaluate Cognitive Evoked Potential and Serum Adiponectin Level in Prediabetes: A Cross Sectional study. Masters thesis, Madras Medical College, Chennai.

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Abstract

BACKGROUND: Prediabetes is more common in young adults. Prediabetes (Impaired Fasting Glucose and Impaired Glucose Tolerance) leads to increased risk of cerebrovascular, cardiovascular changes and overt diabetes. The worldwide prevalence of Impaired Glucose tolerance(IGT) was found to be 343 million (7.8%). Pre-diabetics have an increased risk of developing cerebrovascular and cardiovascular changes. Many studies have shown that there is increased risk of developing cognitive dysfunction in diabetic individuals. Some studies reveal that pre-diabetics are prone for cognitive dysfunction. These changes are likely due to hyperglycemia, insulin resistance, vascular changes and hypoglycaemia. So the objective of this study is to assess the early onset cognitive dysfunction in Pre-diabetics. Adiponectin is an adipocyte derived hormone that plays a protective role against insulin resistance and inflammation and also protects the body against metabolic diseases. It has anti-inflammatory and anti-atherogenic effects. In brain, adiponectin improves insulin signaling and glucose uptake Adiponectin level is altered both in insulin resistance and cognitive impairment. So adiponectin can be taken as a marker to evaluate the cognition in pre-diabetic individuals. Long latency evoked potentials are related to cognitive processing and are referred to as cognitive evoked potential (CEP). P300 is the most frequently investigated CEP appearing at about 300 ms following task-related stimuli. This test reflects the subject's cognitive skill level and verifies whether disorders are present in the auditory association cortex. So cognitive evoked potential is used to evaluate the early cognitive dysfunctions in Pre-diabetic individuals. The earliest changes in cognitive dysfunctions can be picked by evaluating patient’s cognitive evoked potential. And also adiponectin has a significant role in cognitive functions. So in this study, the objective is to evaluate the cognition in pre-diabetic individuals by assessing the patient’s cognitive evoked potential and serum adiponectin level. AIM OF THE STUDY: To evaluate whether cognition is impaired in the pre-diabetic patients when compared to that of clinically healthy individuals and to find its association with serum adiponectin level in the pre-diabetic patients OBJECTIVES: 1. To estimate the change in variables of cognitive evoked potential response in the Pre-diabetic individuals and to compare the same with clinically normal healthy individuals of the study group. 2. To estimate and compare the variations in serum adiponectin level between the prediabetic patients and clinically normal healthy individuals. 3. To find if any association exists between the serum adiponectin level and parameters of the cognitive evoked potential response like latency (ms) and amplitude (mvolt) among the study group. MATERIALS & METHODS: This is a descriptive cross-sectional study conducted during the year 2018-19 in Rajiv Gandhi Government General Hospital (RGGGH), Madras Medical College. This study consisted of fifty prediabetic patients in the age group of 25 – 50 years who were selected based on ADA prediabetic guidelines (case study group) and fifty clinically healthy individuals of both the gender in the age group of 25-50 years (control group). The BMI, the fasting blood glucose levels, the post load blood glucose levels were obtained. The parameters of cognitive evoked potential (N1 latency, P2 latency, N2 latency, P300 latency and N2-P300 amplitude) were recorded. Serum adiponectin levels were measured using ELISA. RESULTS: Prediabetic patients showed cognitive decline with prolonged latencies (N1, N2, P2 and P300) and decrease in N2-P300 amplitude which were statistically significant (P<0.05). Serum adiponectin was increased significantly in prediabetic patients than clinically healthy normal individuals (P<0.05). Serum adiponectin correlated positively with P300 latency and serum adiponectin correlated negatively with N2-P300 amplitude which was statistically significant (P<0.05). CONCLUSION: Prediabetic patients showed a significant prolongation in latencies and decrease in N2-P300 amplitude when compared to that of clinically healthy normal individuals. Also serum adiponectin levels were increased in prediabetic patients significantly and its levels correlated negatively N2-P300 amplitude. So we can conclude from the present study that the prediabetic patients should be screened for cognitive decline to detect early cognitive impairment if any.

Item Type: Thesis (Masters)
Additional Information: 201715003
Uncontrolled Keywords: Prediabetes, Cognition, Adiponectin.
Subjects: MEDICAL > Physiology
Depositing User: Subramani R
Date Deposited: 30 Jan 2021 16:40
Last Modified: 01 Mar 2021 03:29
URI: http://repository-tnmgrmu.ac.in/id/eprint/13483

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