Early Diagnosis of Oral Cancer by Exfoliative Cytology using Methylene Blue and Correlation with Biopsy and Special Stains in GMKMC, Salem

Kokila, V (2020) Early Diagnosis of Oral Cancer by Exfoliative Cytology using Methylene Blue and Correlation with Biopsy and Special Stains in GMKMC, Salem. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.

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Abstract

BACKGROUND: Oral Cancer is global health problem with increasing incidence and mortality rates. Around 3, 00,000 patients annually estimated to have oral cancer worldwide. Oral cancer is accounting for 40% of all cancers in the Indian subcontinent. Hence, there is a need to promote early diagnosis of oral cancer. AIM OF THE STUDY: To evaluate the sensitivity, specificity and accuracy of brush cytology in the detection of oral premalignant and malignant lesions in comparison to histopathology. MATERIALS AND METHODS: A total of 70 cases with oral lesions were included in the study. All patients underwent oral brush cytology and followed by surgical biopsy. Sensitivity, specificity, positive and negative predictive values were calculated. Cytology and histopathology of premalignant and malignant lesions were compared. RESULTS: In this study oral cancer is most common in male. Premalignant and malignant lesions were more common in the buccal mucosa. 3 cases were found false negative. The sensitivity, specificity, positive predictive value and negative predictive value were 95%, 100%, 100% and 77%, respectively. The diagnostic accuracy was 96%. CONCLUSION: Brush cytology using a tooth brush is reliable and can be easily performed with less cost and discomfort to the patient. It is useful in those situations when a patient refuses to have a biopsy performed or when medically compromised patients would be exposed to unnecessary surgical risks. It can be used for screening for suspicious oral lesions and may have applications in resource-challenged areas.

Item Type: Thesis (Masters)
Additional Information: 201713754
Uncontrolled Keywords: Brush cytology, Oral squamous cell carcinoma, Dysplasia, Surgical biopsy, Oral potentially malignant disorders, Adverse habits, Statistical analysis, Correlation.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 17:39
Last Modified: 29 Jan 2021 17:39
URI: http://repository-tnmgrmu.ac.in/id/eprint/13426

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