Correlation of Imprint Smear Cytology with Histology of Endoscopic Biopsies from Upper Gastrointestinal Tract Lesions and Its Diagnostic Utility

Hari Baskaran, K (2020) Correlation of Imprint Smear Cytology with Histology of Endoscopic Biopsies from Upper Gastrointestinal Tract Lesions and Its Diagnostic Utility. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.


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BACKGROUND: Upper GIT is a common site for malignant tumors. Globally, Gastric cancer is the fifth most common and Cancer Esophagus is the eighth most common cancers among both sexes. Histopathological examination of endoscopic biopsies from these lesions remains the gold standard method of diagnosis. Imprint smear cytology is a rapid inexpensive technique to categorise these lesions. Despite being clinically useful, imprint cytology is not routinely performed in a tertiary care centre. The present study was undertaken to evaluate its utility in diagnosing the lesions of upper gastrointestinal tract and its correlation with histopathology. AIM OF THE STUDY: To correlate imprint cytology with histopathology of tissue biopsies of upper GIT lesions. ,to evaluate the utility of imprint smear cytology in the diagnosis of the lesions of upper gastrointestinal tract and to study the endoscopic features in relation with cytology and histopathology. MATERIALS AND METHODS: This was a prospective study conducted on 50 patients attending Medical Gastroenterology department, GMKMCH, Salem over a period of 2 years presenting with symptoms of upper GIT lesions. Endoscopic biopsies were obtained from these patients and imprint smears were made from these biopsy samples and the same biopsy samples were fixed in 10% neutral buffered formalin and sent for histopathological examination. Histopathological evaluation of the endoscopic biopsies was done by histopathologists who were blinded to the imprint cytology smear findings and diagnoses OBSERVATION AND RESULTS: Statistical analyses comparing the results of imprint cytology and histopathology was done on the basis of chi square. On comparison with histopathology, imprint cytology had a sensitivity of 83.33%, specificity of 92.75%, positive predictive value of 88.24% and negative predictive value of 90.91%. Overall diagnostic accuracy was 88.54%. CONCLUSION: To conclude the study Imprint cytology it is a rapid, inexpensive method to categorise malignant and benign lesions with a good sensitivity rate. It is highly specific for malignant lesions. The limitation of imprint smear cytology is that the depth of invasion cannot be identified.

Item Type: Thesis (Masters)
Additional Information: 201713753
Uncontrolled Keywords: Imprint Smear Cytology, Histology of Endoscopic Biopsies, Upper Gastrointestinal Tract Lesions, Diagnostic Utility.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 17:36
Last Modified: 29 Jan 2021 17:36

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