A Clinicopathological study of Hypopigmentary Disorders of Skin, in patients attending the Government Mohankumaramangalam Medical College Hospital, Salem

Ezhilarasi, C (2020) A Clinicopathological study of Hypopigmentary Disorders of Skin, in patients attending the Government Mohankumaramangalam Medical College Hospital, Salem. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.

[img]
Preview
Text
200301020ezhilarasi.pdf

Download (3MB) | Preview

Abstract

BACKGROUND: Hypopigmentary disorders in darker skin individuals like Indians can be distressing to the patients and the family. These disorders cover a wide range of pathologies including infections, inflammatory disorders, autoimmune diseases, lymphoproliferative disorders, and sclerosing diseases. Histological diagnosis is very important because treatment and prognosis for these diseases are varied and specific. AIM OF THE STUDY: To study the correlation of histopathological findings, IHC reactivity and clinical findings of hypopigmented disorders of skin and to assist in diagnosing the difficult and overlapping hypopigmented disorders of skin and thus reducing patient distress. MATERIALS AND METHODS: A total of 53 cases with hypopigmented lesions of skin were included in the study. Skin biopsy was taken and the histopathology was studied. Special stain and immunohistochemistry with HMB45 was done for relevant cases. The correlation of clinical diagnosis and histopathological impression were observed. RESULTS: In this study a total of eleven different diagnoses of hypopigmented disorders were compared and the Clinicopathological correlation observed was 86.7% of cases. Of which pityriasis versicolor showed 83.3%, Lichen striatus showed 50%, PLC showed 66.6% correlation and parapsoriasis showed 33.3%correlation. IHC helped in confirming the diagnosis. CONCLUSION: Histopathological examination helps in arriving at a specific etiology and good clinicopathological correlation. A systematic approach of clinical, histopathological examination and Immunohistochemistry will provide an accurate diagnosis of hypopigmented disorders and thereby reducing the patient distress.

Item Type: Thesis (Masters)
Additional Information: 201713752
Uncontrolled Keywords: hypopigmented lesions, skin biopsy, pityriasis versicolor, Hansen’s disease, vitiligo, LSA, IGH, Lichen striatus, PLC, parapsoriasis, Woronoff ring, DLE, PMLE, HMB 45, PAS stain, Modified fite stain, clinicopathological correlation.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 17:33
Last Modified: 29 Jan 2021 17:33
URI: http://repository-tnmgrmu.ac.in/id/eprint/13424

Actions (login required)

View Item View Item