Expression of ER, PR, KI 67 and CA125 in Ovarian Surface Epithelial Tumors with reference to TNM Staging of the Disease

Sruthi, R (2020) Expression of ER, PR, KI 67 and CA125 in Ovarian Surface Epithelial Tumors with reference to TNM Staging of the Disease. Masters thesis, Tirunelveli Medical College, Tirunelveli.

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Abstract

INTRODUCTION: Ovarian cancer is the 6th most common cancer worldwide. Most of the tumors are epithelial in origin. Ovarian surface epithelial tumor cells are characterized by increased expression of steroid hormone receptors (ER&PR), CA125 and show high proliferative activity. 80% of patients with epithelial ovarian cancer have elevated serum CA125 levels at diagnosis. AIM OF THE STUDY: To study the immunohistochemical profile of ER, PR, CA 125, Ki67 and serum CA125 in surface epithelial ovarian tumors according to their corresponding TNM staging. MATERIALS AND METHODS: This study included 61 patients diagnosed clinically, radiologically and histopathologically as having ovarian tumors. Pre –operative blood samples were collected and assessed for serum values of CA 125. Their corresponding tissue samples were also collected and subjected to histopathological & immunohistochemical studies ( ER, PR, Ki67 and CA125). RESULTS: Out of 61 cases, ER, PR expression was more in benign tumors (39.34% & 31.14%) and in stage IA tumors (45.90% & 39.34%). Higher expression of Ki 67 and tissue CA 125 was also observed in benign tumors (14.75% & 44.26%) and in stage IA tumors (21.31% & 50.81%). 29 patients (48%) showed higher values of serum CA125 and 19 among them showed higher expression of tissue CA125. CONCLUSION: Hence this study concludes that higher expression of ER, PR, CA 125 and Ki 67 is observed in stage I tumors whereas negativity is observed more in stage III- IV tumors. Also elevated serum CA125 values correlates with higher expression of tissue CA125.

Item Type: Thesis (Masters)
Additional Information: 201713306
Uncontrolled Keywords: Epithelial ovarian tumors, serum CA125.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 17:22
Last Modified: 29 Jan 2021 17:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/13421

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