Analysis of AgNOR Count and SAPA Score in FNAC of Breast Neoplasms

Shiny Latha, P (2020) Analysis of AgNOR Count and SAPA Score in FNAC of Breast Neoplasms. Masters thesis, Coimbatore Medical College, Coimbatore.

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Abstract

BACKGROUND: Breast Carcinoma is one of the most common neoplasms in women and is a leading cause of cancer related deaths worldwide. Fine needle aspiration (FNA) is a rapid method for diagnosing breast lesions as an outpatient procedure. Nucleolar Organizer regions (NORs) is the earliest proliferation marker, which are increased in malignant neoplasms compared to benign neoplasms. OBJECTIVES: 1. To analyse the Clinical and Cytomorphological features of Breast Neoplasm. 2. To correlate the AgNOR count and SAPA score of Breast neoplasms in FNAC with Histopathology. MATERIALS AND METHODS: This was a prospective study of FNAC and subsequent Histopathology of available cases in Breast neoplasms among 100 cases undertaken in the Department of Pathology, Coimbatore Medical College and Hospital, Coimbatore during the study period of about two years (July 2017 to June 2019). RESULTS: In our study, the mean AgNOR count in cytology correlated with histopathology reveals 3.4 +/- 0.905 and SAPA score was 6.82 +/- 1.585 among benign lesions of breast. In malignant lesions, the mean AgNOR count and SAPA score was 6.252+/- 1.763 and 11.33 +/- 2.253 respectively. CONCLUSION: AgNOR count and SAPA score reflects the proliferative activity of the cell in which AgNOR dots are quite increased in malignant neoplasms compared to the benign. Mean AgNOR count and SAPA score together provides better accuracy for distinguishing malignant from benign neoplasms.

Item Type: Thesis (Masters)
Additional Information: 201713257
Uncontrolled Keywords: FNAC, AgNOR count and SAPA score.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 16:50
Last Modified: 29 Jan 2021 16:50
URI: http://repository-tnmgrmu.ac.in/id/eprint/13413

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