Analysis of Clinical and Histomorphological Features of Endometrium in Abnormal Uterine Bleeding- E with Special Stain Application

Preethi, R (2020) Analysis of Clinical and Histomorphological Features of Endometrium in Abnormal Uterine Bleeding- E with Special Stain Application. Masters thesis, Coimbatore Medical College, Coimbatore.

[img]
Preview
Text
200300720preethi.pdf

Download (6MB) | Preview

Abstract

BACKGROUND: The most common clinical presentation in the gynecological practice, a condition which requires an extensive, as well as an immediate diagnosis and treatment, prioritized the Abnormal Uterine Bleeding (AUB) as the area for our research study. Among the subtypes of AUB, AUB-E (Endometrial causes) was chosen as a specific foci as it demands an evident histo-pathological parameters to substantiate its clinical diagnosis. MATERIALS AND METHODOLOGY: After obtaining due ethical approval, a prospective study was conducted in the tertiary health care hospital of Coimbatore, among 100 females of reproductive and peri-menopausal age who came with the complaints of AUB, clinically diagnosed as AUB-E. H&E and PAS staining was done on the the endometrial biopsy specimens taken. RESULTS: The incidence of AUB-E was more common in the 40-44 years age group and who had parity score of 2.HMB was the most common complaint. In H&E staining,the most common HPE impression was proliferative endometrium with glandular and stromal breakdown (23%), the least was tuberculous endometritis (1%). Glandular breakdown, the HPE parameter had a statisitical significance among the age group of 40-44 years and parity of score 2. In PAS staining,PAS granules 1+ had statisitical significance among the age group of 40-44 years and parity of score 2. DISCUSSION: There was a positive correlation between glandular breakdown and PAS granules. Hence hypoxia which induces glycogen accumulation shown by PAS granules, indirectly is proportional to glandular breakdown, which makes hypoxia, a potent causative factor for AUB-E. CONCLUSION: Owing to the limitation of sample size due to time and resource constraint (100), there was statistical mismatch with frequency distribution for other parameters, which will be sorted by increase of sample size in the near future, in addition the study will be supported by radiological parameters.

Item Type: Thesis (Masters)
Additional Information: 201713255
Uncontrolled Keywords: AUB, AUB-E, Glandular breakdown, PAS 1+, Hypoxia.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 16:44
Last Modified: 29 Jan 2021 16:44
URI: http://repository-tnmgrmu.ac.in/id/eprint/13411

Actions (login required)

View Item View Item