Analysis of spectrum of pathological changes by Foetal autopsy in cases of Foetal urinary tract obstruction in correlation with antenatal USG findings

Amudha, J (2020) Analysis of spectrum of pathological changes by Foetal autopsy in cases of Foetal urinary tract obstruction in correlation with antenatal USG findings. Masters thesis, Chengalpattu Medical College and Hospital, Chengalpattu.

[img]
Preview
Text
200300620amudha.pdf

Download (3MB) | Preview

Abstract

INTRODUCTION: Congenital urinary tract obstruction is a complex disorder resulting in chronic kidney disease and end stage renal disease. Still the pathogenesis remains unclear. Even though there are various diagnostic modalities available, the amount of renal loss and the bladder changes is not predictable. Foetal autopsy and histopathological examination remains a valuable tool in assessing the degree of dysplasia. OBJECTIVES: This study is done to observe the morphological changes in kidney and bladder at different levels of obstruction grossly, to quantify the degree of dyplasia histopathologically and to determine the relationship between variable factors with degree of dysplasia of kidney and bladder changes. MATERIALS AND METHODS: A total of 40 cases which includes one case of upper urinary tract obstruction and 39 cases of lower urinary tract diagnosed by antenatal ultrasound and confirmed by autopsy. Tissue from the kidney and urinary bladder are formalin fixed and paraffin embedded. Sections were cut at 4μm thickness and stained with haemotoxylin and eosin stain. Degree of renal dysplasia was graded accordingly. RESULTS: Among 39 cases of LUTO, 24 cases had level of obstruction at urethra, 10 cases at posterior urethral valve and in 5 level of obstruction not made out. The higher degree of dysplasia was grade III followed by grade II among 40 cases. 23 cases developed bladder hypertrophy and 16 showed thinned out bladder and in one case it was normal. The relationship between gestational age and degree of dysplasia, degree of dysplasia and bladder changes was statistically significant. CONCLUSION: Earlier diagnosis and intervention at earlier weeks of gestation before significant renal loss occur may be useful. Further studies are recommended in this perspective.

Item Type: Thesis (Masters)
Additional Information: 201713501
Uncontrolled Keywords: Foetal urinary tract obstruction, level of obstruction, Kidney and bladder changes.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 16:22
Last Modified: 29 Jan 2021 16:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/13405

Actions (login required)

View Item View Item