Immunohistochemical Evaluation of Diagnostic and Prognostic Role of Galectin-3 in Papillary Thyroid Carcinoma

Priyadharshini, M (2020) Immunohistochemical Evaluation of Diagnostic and Prognostic Role of Galectin-3 in Papillary Thyroid Carcinoma. Masters thesis, Stanley Medical College, Chennai.

[img]
Preview
Text
200300220priyadharshini.pdf

Download (3MB) | Preview

Abstract

BACKGROUND: Papillary thyroid carcinoma is becoming the common carcinomas among Indian population. Galectin-3 is expressed in most of the papillary thyroid carcinomas which is used for the definitive diagnosis and to evaluate the prognosis of the disease. Galectin-3 is a member of the beta-galactoside-binding protein family that plays an important role in cell - cell adhesion, cell - matrix interactions, macrophage activation, angiogenesis, metastasis and apoptosis. Galectin-3 overexpression promotes neoplastic transformation and the maintenance of transformed phenotypes as well as enhances the tumour cell's adhesion to the extracellular matrix and increase metastatic spreading. Galectin-3 targeted therapy is a promising therapeutic strategy for advanced PTC that is refractory to surgery and radioactive iodine therapy. Hence the study helps in definitive diagnosis and predicts the prognosis of papillary carcinoma thyroid. AIMS AND OBJECTIVES: To diagnose papillary thyroid carcinoma in cases with suspicious of malignancy using Galectin-3. To estimate the immunohistochemical expression of Galectin 3 in papillary thyroid carcinoma and to correlate the expression of Galectin-3 in tumor cells and with prognostic parameters. RESULTS: 40 blocks of papillary thyroid carcinoma and 20 blocks of adenomatous hyperplasia were obtained from the Department of Pathology, Government Stanley medical college. Among the cases in papillary thyroid carcinoma group, 28 (70%) cases were positive for Galectin-3 expression and 12 (30%) cases were negative for Galectin-3 expression. Among the cases in adenomatous hyperplasia group, 4 (20%) cases showed positive galectin-3 expression and 16 (80%) cases showed negative galectin-3 expression. The difference in the expression of Galectin-3 between papillary thyroid carcinoma and adenomatous hyperplasia was statistically significant. (P value <0.001). The difference in galectin-3 expression in cases with and without nodal metastasis was statistically significant. (P value 0.038) implying that higher galectin-3 expression was seen in cases with nodal metastasis. CONCLUSION: There was a significant difference in the expression of Galectin-3 between papillary thyroid carcinoma and adenomatous hyperplasia. This emphasised the diagnostic role of Galectin-3 in differentiating papillary thyroid carcinoma from benign adenomatous hyperplasia. Significant increase in Galectin-3 expression was observed in cases of papillary thyroid carcinoma with lymph node metastasis. This shows the prognostic role of Galectin-3 in papillary thyroid carcinoma. Because of its significant expression in papillary thyroid carcinoma, Galectin-3 is one of the promising target proteins for cancer treatment.

Item Type: Thesis (Masters)
Additional Information: 201713053
Uncontrolled Keywords: Papillary thyroid carcinoma, Galectin-3, Thyroid, Lymph node metastasis.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 16:08
Last Modified: 29 Jan 2021 16:08
URI: http://repository-tnmgrmu.ac.in/id/eprint/13402

Actions (login required)

View Item View Item