Sridhar, S (2020) A Study of Hematological Indices and Histogram Findings in Clinically Suspected Malarial Fever in Comparison with Gold Standard Test for Malaria for Rapid Screening. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Hematological abnormalities are considered a hallmark of malaria various studies have confirmed the same. Malaria causes various immune response like innate and acquired immunity which involves both cellular and humoral immunity which varies from one person to another adding on to its pathogenicity. Automated analyzers generated reports with altered CBC parameters and their histogram flags can be useful clue to diagnose malaria at the primary health care level even by semi skilled heath workers in comparison with thick and thin blood smear examination by microscopy which is gold standard test for diagnosing malaria. AIM OF THE STUDY: To evaluate the usefulness of automated cell counters analyzing the hematological parameters, their histograms, and the flags generated from the blood samples of Clinically suspected malaria cases in comparison with gold standard test for malaria for rapid screening. MATERIAL AND METHODS: This is a prospective study conducted in institute of pathology at Rajeev Gandhi Government General Hospital Chennai. Blood samples from 200 clinically suspected malaria samples obtained in EDTA anti-coagulant tube and run in automated analyzers and all the hematological parameters of blood and the histogram flags generated were studied. RESULTS: Any CBC with anaemia, leucopenia, pseudoeosinophilia with thrombocytopenia along with abormal WL flag in wbc histogram with or with out the flag in the mixed zone in WBC histogram and abnormal flag platelet histogram is highly suspicious for malaria infection. CONCLUSION: Any case with anaemia, leucopenia, pseudoeosinophilia with thrombocytopenia along with abormal flag in wbc histogram specific of malarial infection and abnormal platelet histogram is highly suspicious for malaria infection especially in the endemic zone and remote rural areas where microscopy diagnosis, QBC and other invasive tests are not feasible to diagnose malaria to initiate emperical antimalarial treatment for the population under risk. All these tests though not officially approved to diagnose malaria by WHO can be used to catch malaria in early stage in asymptomatic individuals also with the knowledge of these graphs & patterns paramedical staff, resident doctors, senior pathologists & even treating physicians might not miss malarial parasites even in the absence of a clinical request. More slides will be reviewed to ensure no case is missed and delayed from initiating antimalarial treatment at the earliest at the primary level. With consistantly good sensitivity and specificity as shown by various previous studies. Its time to look into the practical implementation of such observation and get the diagnostic clue to diagnose malaria even if chills and rigor pattern of disease is not manifested.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201713008 |
| Uncontrolled Keywords: | Anemia, leucopenia, pseudoeosinophilia, Thrombocytopenia, WBC histogram. |
| Subjects: | MEDICAL > Pathology |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Jan 2021 15:39 |
| Last Modified: | 29 Jan 2021 15:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13398 |
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