Clinical and Immunohistopathological study of Dermatological Lesions in a Tertiary Care Centre

Mohanapriya, L (2020) Clinical and Immunohistopathological study of Dermatological Lesions in a Tertiary Care Centre. Masters thesis, Madras Medical College, Chennai.

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Abstract

BACKGROUND: It is essential to make a rapid and accurate diagnosis in order to classify the disease, to plan a proper treatment protocols and also to predict the prognosis for the patients. But in many patients due to heterogeneous symptoms, atypical appearance of lesions, accurate diagnosis in dermatological disorders remain challenging for the dermatologist and physicians. In such circumstance immunofluorescence is a very useful tool to aid an accurate diagnosis. AIM OF THE STUDY: 1. To analyse clinical picture, histopathological finding with direct immunofluorescence[DIF]. 2. To access the role of direct immunofluorescence in the evaluation of dermatological disorders. MATERIALS AND METHODS: The present study was a prospective analytical study in skin biopsies of patients with vesiculobullous disorder, connective tissue, disorder and with vasculitis. This study was conducted over a period of 1.5 years with 100 cases. The biopsies were received from the Department of dermatology, Madras Medical College & Rajiv Gandhi Govt. General Hospital, Chennai. Clinical picture, histopathological findings and direct immunofluorescence findings were analysed in this study and results were taken for the final conclusion. RESULTS: In dermatological disorders combined analysis of clinical picture, histopathological examination and direct immunofluorescence yield more accurate results. Direct immunofluorescence [DIF] plays an important role in the diagnosis even when the histopathological results are inconclusive. CONCLUSION: In dermatological disorders combined analysis of clinical picture, histopathological examination and direct immunofluorescence yield more accurate results. Direct immunofluorescence [DIF] plays an important role in the diagnosis even when the histopathological results are inconclusive. In every case of clinically suspected immunobullous disorder, DIF must be done for the classification of the condition thereby lead to proper treatment and better outcome.

Item Type: Thesis (Masters)
Additional Information: 201713005
Uncontrolled Keywords: Direct immunofluorescence,histopathological examination, vesiculobullous disorder.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 15:24
Last Modified: 29 Jan 2021 15:24
URI: http://repository-tnmgrmu.ac.in/id/eprint/13395

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