Expression of CD163 in Tumor Associated Macrophages in the Microenvironment of Breast Carcinomas with Special Reference to Cancer Dormancy

Gowri Manohari, D (2020) Expression of CD163 in Tumor Associated Macrophages in the Microenvironment of Breast Carcinomas with Special Reference to Cancer Dormancy. Masters thesis, Madras Medical College, Chennai.

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Abstract

BACKGROUND: Breast carcinoma is the most common malignancy and the most common cause of cancer death in women with more than 1.7 million cases occurring worldwide annually. Significant increase in survival rate is evident since 1990s owing to dramatic increase in screening modalities. Though early detection and treatment aims at increased survival rates, most of them recur or metastasise to distant organs.Tumor associated macrophages is one of the factors among many in the Tumor micro environment that plays a crucial role in metastasis and recurrence. This study aims at evaluating Tumor associated macrophages by Immunohistochemistry using cCD 163. AIMS AND OBJECTIVES: 1. To correlate Tumor associated macrophages with Tumor grade. 2. To correlate Tumor associated macrophages with hormonal status of the Tumor. 3. To correlate Tumor associated macrophages with chemotherapy status. MATERIALS AND METHODS: This study was conducted at Institute of Pathology, Madras Medical College gm from July 2017 to July 2019, 404 were malignant tumors. Of the 404 cases, 100 cases were selected randomly by evaluated for Tumor associated macrophages. 4 micro meter sections were subjected to immunohistichemistry as per standard protocols. Macrophage infiltration was scored as low, moderate and high infiltration as per statistical analysis. RESULTS: In present study, most common age group affected was 51-60 years. 50% were right sided. Mean Tumor size is 2-5cm and most of them were grade II Tumors. Tumor associated macrophages infiltration did not correlate with size, nodal status, lymphovascular invasion and Perineural invasion. Significant P value is obtained for Tumor grade and triple negative tumors Which emphasises their poor prognosis. CONCLUSION: Several factors in the Tumor micro environment orchestrates the macrophages from their tumoricidal to tumorigenic property which plays a vital role in angiogenesis, metastasis Asia well as recurrence. Tumor associated macrophages can be targeted along with standard therapies thereby aiming at complete elimination of the Tumor cells and disease free survival.

Item Type: Thesis (Masters)
Additional Information: 201713002
Uncontrolled Keywords: Tumor micro environment, Tumor associated macrophages, CD163, triple negative tumors, Immunohistochemistry.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jan 2021 15:04
Last Modified: 29 Jan 2021 15:04
URI: http://repository-tnmgrmu.ac.in/id/eprint/13392

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