Kanchanadevi, V (2020) Clinical, Biochemical and Imaging Profile in Dengue Fever in PSG Institute of Medical Sciences and Research, Coimbatore: A Prospective Observational study. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.
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Abstract
INTRODUCTION: Dengue is the most common mosquito borne arbo viral disease with increased outbreaks annually in tropical and subtropical regions of the world. In recent decades, global incidence of dengue has been grown dramatically. About half of the world's population is now at risk of developing infection with dengue. In India, in almost all states dengue is an endemic disease. It is one of the leading cause of hospitalization. OBJECTIVES: Primary Objectives: To evaluate the clinical, biochemical and imaging profile of 100 patients with dengue NS 1 Positive / Dengue Ig M /Ig G positive cases. Secondary objective: 1. To evaluate the complications secondary to dengue infection. 2. To evaluate the need for platelet transfusion in dengue infection MATERIALS AND METHODS: A prospective observational study. Patients aged > 16 years of age and those who are admitted in male and female medical wards, IMCU and MICU with positive dengue serology (Dengue NS 1 Ag / Dengue IgM /IgG Antibody) of 100 patients for a period of one year from January 2018 to December 2018 RESULTS: A total of 100 patients admitted to our hospital with fever and dengue serology positive were studied. Out of 100 patients, 53 (53%) were diagnosed to have dengue fever with warning signs was the most common presentation. 45 (45%) patients had dengue fever without warning signs & 2 (2%) patients had severe dengue. Young males were most commonly affected. Most common presentation was fever followed headache and joint pain, myalgia. Petechiaeand malena were the most common bleeding manifestations. Thrombocytopenia was seen in all patients followed by leucopenia (50%). 34 (34%) patients had severe thrombocytopenia (< 20,000 cells / cu mm). There was a negative correlation between haematocrit and platelets and was insignificant. 86 (86%) patients had elevated AST levels, 65 (65%) patients had elevated ALT levels. Gall bladder wall thickening and edematous gall bladder was the most common ultrasonographic findings followed by ascites, hepatomegaly was seen. 32 (32%) patients were transfused with platelets. 2 patients had severe dengue with hypotension. All patients had good recovery. CONCLUSION: To conclude, in this study dengue fever with warning signs was the most common clinical presentation followed bydengue fever without warning signs &severe dengue. Most of the patients presented with classical features such as fever, headache, arthralgias, myalgias, rash, and bleeding manifestations. Thrombocytopenia was seen in all patients followed by leucopenia. Petechiae and malena was the common bleeding manifestations. Two patients had shock and recovered. Thrombocytopenia does not have any correlation with bleeding manifestations and severity of dengue infection. The treatment of dengue is mainly supportive. However, appropriate fluid management plays a major role in outcome of the disease.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201711501 |
| Uncontrolled Keywords: | Clinical, Biochemical, Imaging Profile, Dengue Fever, Prospective Observational study. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jan 2021 19:14 |
| Last Modified: | 30 Jan 2021 14:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13357 |
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