Correlation of Carotid Artery Tunica Intima Medial Thickness in Different Stages of Chronic Kidney Disease (CKD) as a Marker of Atherosclerosis

Praveen, G (2020) Correlation of Carotid Artery Tunica Intima Medial Thickness in Different Stages of Chronic Kidney Disease (CKD) as a Marker of Atherosclerosis. Masters thesis, Tirunelveli Medical College, Tirunelveli.

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Abstract

BACKGROUND: Chronic Kidney disease is a significant predictor of cardiovascular mortality. Accelerated atherosclerosis is common in CKD patients and hence more prone for cardiovascular disease(CVD) mortality. Carotid intimal medial thickness (CIMT) is a direct marker of atherosclerosis which can be measured non-invasively using B mode ultrasonography to detect early atherosclerosis. OBJECTIVES: To study The relationship between CIMT as a surrogate marker of atherosclerosis in CKD independent of classical risk factors and relationship between CIMT of hemodialyzed CKD patients and CKD patients without hemodialysis. METHODS: 50 CKD patients were subjected to relevant blood investigations, carotid artery Doppler and studied for relationship of CIMT with risk factors. RESULTS: In our study we found that CIMT increased progressively with CKD progression and had an independent positive correlation. Compared to normal population the mean CIMT was higher in CKD patients. The mean CIMT correlated positively with traditional risk factors for atherosclerosis like age, diabetes, hypertension, smoking. The mean CIMT was significantly higher in patients undergoing hemodialysis than patient not undergoing hemodialysis. There is no correlation n between gender and CIMT. CONCLUSION: Hemodialysis acts as a significant risk factor for accelerated atherosclerosis. Aggressive management of risk factors in these patients helps in reducing incidence of vascular events.

Item Type: Thesis (Masters)
Additional Information: 201711364
Uncontrolled Keywords: Atherosclerosis, Chronic Kidney Disease, Carotid intimal medial thickness.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 18:37
Last Modified: 29 Jan 2021 08:33
URI: http://repository-tnmgrmu.ac.in/id/eprint/13328

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