Evaluation of Cardiovascular Manifestations in Systemic Lupus Erythematosus Patients in a Tertiary Care Hospital

Lakshmi Rani, B (2020) Evaluation of Cardiovascular Manifestations in Systemic Lupus Erythematosus Patients in a Tertiary Care Hospital. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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INTRODUCTION: Cardiovascular mortality is the leading cause of mortality in SLE patients. Its more common manifestations include pericarditis, valvular infections, conduction disorders, arterial hypertension. OBJECTIVES OF THE STUDY: 1. To assess the frequency of cardiovascular events in the SLE patients during the study period. 2. Follow up of SLE patients for early diagnosis of cardiovascular events. INCLUSION CRITERIA: 1. Patients of both sexes. 2. All SLE patients attending the rheumatology OPD in Tirunelveli medical college during the study period. EXCLUSION CRITERIA: 1.Diagnosed cases of other associated autoimmune disease like Sjogren’s syndrome, rheumatoid arthritis, hashimoto’s thyroiditis. 2.Diagnosed cases of cardiovascular disease due to other comorbidities like diabetes mellitus, hypertension. RESULTS: The most common cardiovascular manifestation in the systemic lupus erythematosus patients is the pericarditis/ pericardial effusion. The least common cardiovascular manifestation being the global hypokinesia found in echocardiography. The systemic lupus erythematosus patients who developed cardiovascular complications are well responding to corticosteroids. CONCLUSION: In our study 80% of patients had the cardiovascular manifestations. Valvular heart disease is the second most common manifestations after pericardial effusion, Mitral regurgitation / Mitral valve prolapse being the second most manifestation accounting for 28% of SLE patients in our study. Systemic hypertension is found in 32% of patients in our study. Pulmonary hypertension occurs in 16% of SLE Patients in our study. Almost all the cardiovascular manifestations found in this study coincides with the literature except for the higher prevalence of pulmonary hypertension.

Item Type: Thesis (Masters)
Additional Information: 201711360
Uncontrolled Keywords: Anti nuclear antibody (ANA), Double stranded DNA (ds-DNA), complete blood count (CBC), renal function test (RFT), liver function test (LFT), electrocardiogram (ECG), sustemic lupus erythematosus (SLE).
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 18:34
Last Modified: 29 Jan 2021 07:45
URI: http://repository-tnmgrmu.ac.in/id/eprint/13324

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