Rajeshkumar, S (2020) A Study of Correlation between Platelet and Mean Platelet Volume and Platelet Distribution Width in Determining the Significance and Outcome in Dengue Fever in Tertiary Care Centre, Coimbatore. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
BACKGROUND: Dengue is an endemic disease in subtropical and tropical regions of the world causing severe epidemic in India and is endemic in many parts of India, especially the metropolitancities and towns. Each year an estimated 100 million cases of dengue fever(DF) occur and between 2.5 and 5 lakh cases of dengue hemorrhagic fever(DHF) are reported to WHO. AIMS AND OBJECTIVES: To study the role of platelet parameters like platelet count(PLT), Mean platelet volume(MPV) and Platelet distribution width(PDW) in dengue positive infection and also to note their relationship with the severity of the disease. MATERIALS AND METHODS: The study was done on 100 dengue positive cases during a period of one year from May 2018 to April 2019. The platelet parameters like Platelet count, Mean platelet volume, Platelet distribution width wee noted using Hematology Analyser and was compared with the severity of the disease(DF/DHF). RESULTS: Relationship between platelet parameters like platelet count, MPV and PDW were made with severity of the disease(DF/DHF). Significant difference was observed between severity of the thrombocytopenia and severity of the disease. Dengue positive cases were associated with low MPV and high PDW values in 93% cases. CONCLUSION: Platelet count is thus a predictive parameter of DF/DHF. Low MPV (<9fl) and high PDW(>13fl) shows sensitivity for dengue fever thus reflecting a predictive marker for diagnosing dengue fever in endemic area.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 201711313 |
| Uncontrolled Keywords: | Dengue, mean platelet volume (MPV), platelet distribution width (PDW). |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jan 2021 18:21 |
| Last Modified: | 29 Jan 2021 03:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13308 |
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