A Study to determine fasting lipid profile as a predictor of mortality and morbidity in Dengue Infection

Veeraselvan, S (2020) A Study to determine fasting lipid profile as a predictor of mortality and morbidity in Dengue Infection. Masters thesis, Kilpauk Medical College, Chennai.


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INTRODUCTION: Dengue fever remains the most rapidly spreading mosquito-borne viral disease worldwide and in recent decades a re-emergence of the virus and its severe forms has been observed. Found in the tropical and sub-tropical regions of the world, over 2.5 billion people live in dengue endemic countries, with approximately 50 million dengue infections diagnosed annually. Of those diagnosed, an estimated 500 000 people, the majority being children, develop severe forms of dengue and require hospitalization annually. About 2.5% of those affected do not survive. In recent years, increases in incidence have partly been attributed to urbanization and air travel, and infections are only expected to rise. OBJECTIVES: The objective of the study was to correlate the fasting lipid profile with the Dengue severity and to identify those patients at risk for capillary leakage and coagulopathy. METHODOLOGY: This comparative cross – sectional study was conducted at the Govt.Kilpauk Medical College & hospital in the department of General Medicine All patient attending Medicine / Fever OPD and all inpatients admitted with clinical features suggestive of viral infection were subjected to dengue serology testing. Depending on the day of fever patients were subjected to either NS 1 Antigen or IgM Antibody titre. For all enrolled 132 patients CBC, RFT, LFT, fasting lipid profile, USG Abdomen, Chest X ray, Dengue serology was done and documented in the proforma. Patients were monitored daily throughout critical and convalescent period for any signs of capillary leakage (manifesting as pleural effusion, ascites, gall bladder wall edema and haematocrit >20), bleeding manifestation (manifesting as malena, gum bleeding, menorrhagia, positive hess test and other symptoms like hemoptysis, hematemesis, etc )and shock (manifesting as low blood pressure, narrow pulse pressure, cold peripheries and a haematocrit <20). RESULTS : Out of 132 patients included in the study, 87 were males and 45 were females with most of the patients in age group of 21- 30 years. Out of 62 patients with bleeding manifestations, 60 patients had serum cholesterol less than 100 and all 62 patients had HDL less than 50. Out of 92 patients with capillary leakage 85 patients had serum cholesterol less than 100 and all 92 patients had HDL less than 50. All 52 patients had both total cholesterol less than 100 and HDL less than50 either at the time of admission or during febrile period. CONCLUSION: Serum fasting lipid profile is useful indicator in predicting bleeding manifestation, capillary leakage and shock in dengue and hence in predicting dengue hemorraghic fever/dengue shock syndrome, hereby reducing the mortality and morbidity in dengue.

Item Type: Thesis (Masters)
Additional Information: 201711166
Uncontrolled Keywords: Fasting lipid profile, Dengue Fever, Dengue Hemorrhagic Fever, capillary leakage, bleeding manifestation, shock.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 17:09
Last Modified: 28 Jan 2021 17:09
URI: http://repository-tnmgrmu.ac.in/id/eprint/13275

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