Severity and Prognosis of Acute Organophosphorus Pesticide Poisoning Indicated by C-Reactive Protein and Acute Physiology and Chronic Health Evaluation (APACHE) II Score

Karthik Pandian, T (2020) Severity and Prognosis of Acute Organophosphorus Pesticide Poisoning Indicated by C-Reactive Protein and Acute Physiology and Chronic Health Evaluation (APACHE) II Score. Masters thesis, Madurai Medical College, Madurai.

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Abstract

BACKGROUND: Organo-phosphorus compounds (OPC) are widely used insecticides all over the world. According to statistics, nearly 50% of admissions with acute poisoning in Emergency department are due to Organophosphorus compounds. Their easy accessibility along with socio-cultural factors play a considerable role in the selection of these compounds as a main suicidal agent. Urine tests typically assess the organophosphorus metabolic product content. In addition, the determination of cholinesterase levels in the plasma of patients with Acute organophosphorus pesticide poisoning is widely used in the clinical diagnosis, treatment and prognosis prediction of Acute organophosphorus pesticide poisoning. C-reactive protein (CRP) is a reactive substance in acute lesions, and elevated plasma levels of CRP are a result of inflammation and trauma. In Acute organophosphorus pesticide poisoning, toxins may cause lesions in tissues and organs in the body, leading to increased plasma CRP levels. Therefore, plasma CRP may reflect the degree of lesions caused by Acute organophosphorus pesticide poisoning. AIMS AND OBJECTIVES: 1. To investigate the plasma levels of C-reactive protein and APACHE II score in patients with acute organophosphorus pesticide poisoning. 2. To assess the severity and prognosis of acute organophosphorus pesticide poisoning by C-reactive protein levels and APACHE II score. MATERIALS AND METHODS: It is prospective study conducted on 100 organophosphorus pesticide poisoned patients admitted to Govt Rajaji Hospital Madurai during the study period of 8 months. Patients with pre-existing Infections, Autoimmune diseases, Inflammatory bowel diseases and Malignancy were excluded. APACHE II score was calculated at the time of admission and serum C-reactive protein levels were measured at the time of admission, 24hours and 48 hours later. DISCUSSION: The present study showed that the levels of CRP on admission, 24 hours later and 48 hours later after AOPP and were increased according to the severity of AOPP. In addition, this difference is negatively correlated with the levels of acetylcholine esterase, an indicator that reflects AOPP severity. CONCLUSION: In conclusion, the present study revealed that changes in the CRP, and the APACHE II scoring may be associated with the prediction of AOPP prognosis. ◈ Raised levels of c reactive protein in patients with severe acute organophosphorus pesticide poisoning. ◈ Its significance in the prediction of severity and prognosis in patients with acute organophosphorus pesticide poisoning.

Item Type: Thesis (Masters)
Additional Information: 201711109
Uncontrolled Keywords: Acute organophosphorus pesticide poisoning (AOPP), Organo-phosphorus compounds (OPC), C-REACTIVE PROTEIN (CRP).
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 15:06
Last Modified: 28 Jan 2021 15:06
URI: http://repository-tnmgrmu.ac.in/id/eprint/13251

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