Serial Serum Albumin and Other Liver Parameters Monitoring as a Prognostic Marker in Patients with Sepsis

Jai Ganesh, K (2020) Serial Serum Albumin and Other Liver Parameters Monitoring as a Prognostic Marker in Patients with Sepsis. Masters thesis, Madurai Medical College, Madurai.


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INTRODUCTION: Serum Albumin is the most abundant plasma protein and contribute to 55%-60% of total protein of the body and it is a potent NEGATIVE ACUTE PHASE REACTANT its concentration changes in response to inflammation. severity of liver disease is reflected in clinical signs or biochemical alteration. Hepatic dysfunction & Hypoalbuminaemia indicates poor outcomes in sepsis patients. MATERIALS AND METHODS: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Chronic malnutritions, Chronic liver disease, Nephrotic syndrome, Protein losing enteropathy were excluded from the study. comparison and trend of serum Albumin and other liver parameters over Day 1, 3, 5, 7 of admission were studied among Survivor and Non-survivor irrespective of diagnosis. OBSERVATION AND RESULTS: A statistically significant difference (p<0.05)was observed in the mean serum Albumin on day 3 & increased liver enzymes, bilirubin, INR on day 3 between Survivor and Non-survivor (mean serum Albumin 3.53 and 3.18 respectively). Among the survivor those with higher mean serum Albumin & increased liver parameters on Day 3 had shorter hospital stay, minimized ionotropes support and mechanical ventilation requirements. Hence those patients who recovered from sepsis to have higher serum albumin and near normal liver enzymes on Day 3&5 had a higher chances of survival and reduced ionotropes, mechanical ventilation assist. CONCLUSION: Serum Albumin & LFT parameters on Day 3 &5 correlated directly with higher mortality in sepsis patients.Day 7 serum albumin <2.5g/dl and increased LFT parameters served as a poor prognostic marker.serum Albumin and LFT parameters thus served as simple but very powerful tool for assessing prognosis of Sepsis patients.

Item Type: Thesis (Masters)
Additional Information: 201711107
Uncontrolled Keywords: sepsis, serum Albumin, LFT parameters, day 3 & 5.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 14:56
Last Modified: 28 Jan 2021 14:56

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