A Study on Progression of Gestational Thyroid Disorder to Overt Thyroid Disorder and to Establish the Impact of Thyroid Disorder on Pregnancy Outcome

Mohamed Ibrahim, A (2020) A Study on Progression of Gestational Thyroid Disorder to Overt Thyroid Disorder and to Establish the Impact of Thyroid Disorder on Pregnancy Outcome. Masters thesis, Stanley Medical College, Chennai.

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Abstract

BACKGROUND: Thyroid hormones have profound variation during the life span and are associated with severe adverse health impacts on the normal and pregnant people. The second most common endocrinological disorder in pregnancy is thyroid dysfunction. My study is to see if diagnosed early and adequately treated women with thyroid disorder are able to reduce the complications like spontaneous miscarriages, preeclampsia, preterm labor, IUGR, stillbirth, low birth weight babies. AIM OF THE STUDY: To establish the effect of Thyroid Disorder on pregnancy outcomes in the South-Indian population and to check the rate of progression of Gestational Thyroid Disorders into Overt Thyroid Disorders. MATERIALS AND METHODS: Newly diagnosed pregnant women with Thyroid Disorder attending Endocrinology Out Patient Department were enrolled in the study after institutional ethics approval and consent from the study subjects. The reference ranges of the test values used in this study was as per the Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and Postpartum.The outcome of the pregnancy will be followed up and documented. The TSH and fT4 levels will be estimated at 6 weeks and 6 months postpartum and checked for progression to overt Thyroid Disorder. RESULTS: This study showed a high prevalence of thyroid disorder (11.6%) especially hypothyroidism in pregnant women, with the prevalence of subclinical hypothyroidism being 6.4% and overt hypothyroidism being 2.8%. 8 patients were found to have progressed from Gestational Thyroid Disorders into Overt Thyroid Disorders. CONCLUSION: Our study proved that the rate of progression of gestational thyroid disorder to overt thyroid disorder is 8%. Creating awareness about thyroid disorders in antenatal life can motivate them for postnatal testing, thus preventing the the consequences of thyroid disorders in future life.

Item Type: Thesis (Masters)
Additional Information: 201711059
Uncontrolled Keywords: Effect of Thyroid Disorder, pregnancy, Gestational Thyroid Disorders,Overt Thyroid Disorders.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 12:49
Last Modified: 28 Jan 2021 12:49
URI: http://repository-tnmgrmu.ac.in/id/eprint/13229

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