Kishwanth, R (2020) Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Predictive Markers of Clinical Severity in Cerebral Venous and Sinus Thrombosis. Masters thesis, Madras Medical College, Chennai.
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Abstract
Cerebral venous and sinus thrombosis (CVST), one of the uncommon varieties of cerebrovascular events with an annual incidence ranging from 0.22 to 1.57 per 100,000, mainly affects young and middle-aged adults, and is three times more common among women than men. CVST is now known to have a more varied clinical spectrum of symptoms and can be confirmed only by radiological imaging techniques. For physicians working at hospitals where scope for imaging techniques are remote, a common, easily available surrogate marker would help them diagnose CVST and would help in prompt referral to a higher centre for definitive treatment. This study aims to assess the usefulness of such markers, NLR (Neutrophil to Lymphocyte ratio) and PLR (Platelet to Lymphocyte ratio), correlate them with clinical severity scales like mRS (Modified Rankin Scale) and ISCVT (International Study of Cerebral Vein and dural Sinus Thrombosis). Study population included 96 radiologically confirmed cases of CVST between the age group of 18-60 years and their admission NLR and PLR were calculated and each ratio was correlated with mRS and ISCVT. Majority of them were males. The age group 18 -28 represented the maximum in which majority were post partum females. Thrombosis of central vein of galen was observed in 14 of them. The mean of NLR was observed to be 5.589 (±1.351 SD) and PLR had a mean of 161.898 (± 26.182 SD). Most of the patients had mRS Score 3 and ISCVT score 1. NLR showed linear relationship with both mRS and ISCVT as did PLR with respective p < 0.05. It was concluded that whenever a patient presents with a vague neurological symptom, a hemogram can be done at a primary care level to calculate the ratios and promptly refer the patient to higher centre if the ratios are suggestive of CVST as these ratios were correlated well the severity scoring systems including mRS and ISCVT.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201711008 |
| Uncontrolled Keywords: | Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), International Study of Cerebral Vein and Dural Sinus Thrombosis (ISCVT), Modified Rankin Score) (mRS), Cerebral Venous and Sinus Thrombosis (CVST), post partum, pregnancy, hypercoagulable state, clot. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jan 2021 03:40 |
| Last Modified: | 28 Jan 2021 07:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13208 |
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