A Study on Clinical Profile and Outcome of Acute Kidney Injury in Tropical Febrile Illness admitted in Tertiary Care Centre

Kishore Kumar, R (2020) A Study on Clinical Profile and Outcome of Acute Kidney Injury in Tropical Febrile Illness admitted in Tertiary Care Centre. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND: Acute Febrile Illness is one of the common causes for many hospital admissions. Among them we are mostly exposed to Dengue, Malaria, Leptospirosis, Typhoid, Scrub Typhus and so on. In India, Infections form a important cause of Acute Kidney Injury, which also act as a precursor for CKD. These AKI are easily preventable and treatable if diagnosed earlier and thereby we can reduce the morbidity and mortality. Hence, the onus is on to identify the common cause for AKI among AFI and outcome of AKI. OBJECTIVES: 1. To find the incidence of AKI in Acute Febrile Illness. 2. To Study about the Clinical Profile and outcome of Acute Kidney Injury in Acute Febrile Illness. 3. To follow up the patients to find any persistent renal dysfunction and progression to CKD. METHODS: Patient who were admitted with history of acute febrile illness, were selected for the observational study according to the inclusion and exclusion criteria. Patient who developed Acute Kidney Injury where studied in detail. Investigations like Complete Blood Count, Renal Function Test, Liver Function Test, Serum Electrolytes, Creatinine Phosphokinase, Lactate dehydrogenase, Arterial Blood Gas Analysis, Ultrasound Abdomen, Serology for Dengue, Leptospirosis, Scrub Typhus. Blood Culture for Enteric Fever, Peripheral Smear for Malaria were done. RESULTS: 31 patients developed AKI out of 225. Out of 31 cases, 14 (15.7%) were due to dengue (89 Dengue positive). Malaria (22.2%) and Typhoid (27.3% occupies major proportion among the malaria and typhoid positive cases. Among 31 cases, 11 had oliguric renal failure. Only 5 patients underwent hemodialysis, of which 2 patients died due to Multiorgan Dysfunction. CONCLUSION: This Study showed AKI is more common among males & in older Age Group. Malaria & Typhoid are the common cause of AKI. Dengue fever is the recent emerging cause of AKI. Most of AKI resolved conservatively with IV fluids and Antibiotics. So all AFI patient should be assessed for the risk of AKI development.

Item Type: Thesis (Masters)
Additional Information: 201711007
Uncontrolled Keywords: Acute Kidney Injury, Tropical Fever, Dengue, Malaria, Leptospirosis, Scrub Typhus, Typhoid.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Jan 2021 03:30
Last Modified: 28 Jan 2021 07:38
URI: http://repository-tnmgrmu.ac.in/id/eprint/13207

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