A Study on Correlation of hs-CRP and Lp(a) in Metabolic Syndrome

Pandidurai, M (2012) A Study on Correlation of hs-CRP and Lp(a) in Metabolic Syndrome. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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INTRODUCTION: Metabolic syndrome (MS) is characterized by the presence of a cluster of atherogenic risk factors, and is associated with a marked increase in the risk of cardiovascular disease. In 1999, MS was defined by the World Health Organization (WHO), and in 2001 another definition was proposed by the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on the Detection, Evaluation, and the Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III, ATP III). Further definitions have been proposed recently by various organizations or associations. In an attempt to improve global cardiovascular risk prediction, considerable interest has focused on C-reactive protein (CRP), a marker of inflammation that has been shown in multiple prospective epidemiological studies to predict incidents of myocardial infarction, stroke, peripheral arterial disease, and sudden cardiac death(5,6). Thus, MS using the criteria of WHO and NCEP-ATP III, has been investigated for its possible relation to CRP in this study. AIMS AND OBJECTIVES: 1. To compare the levels of hS-Crp and Lp(a) in patients satisfying the criteria for MS ie.3 or more risk factors with the patients with one or two risk factors who serve as controls. Patients are excluded if they are already taking CAHD drugs, Statins and other chronic inflammatory diseases. 2. To find out the association of Hs-Crp and Lp(a) in metabolic syndrome. MATERIAL AND METHODS: Setting: The study was conducted in the cardiology OPD, Department of Cardiology, Tirunelveli Medical College and Tirunelveli Medical College Hospital, Tirunelveli. Collaboration Department: Cardiology OPD, HT and Diabetic OPD, Department of Medicine. Study Design: Single Centre, Non randomized cross sectional study. Study Period: Study was conducted between December 2010 and November 2011 for a period of 12 months from November 2010 to October 2011. Sample Sizes: In the study period of 12 months patients attending the Cardiology OPD, Department of Cardiology after applying inclusion and exclusion criteria, 50 patients were included in the study. Selection of Study Subjects: The patients in the age group of 31-65 were eligible for the study. It is confirmed that they had not taken statins for 3 months by detail history. Inclusion Criteria: 1. Age group between 31-65 years. 2. Patients satisfying metabolic syndrome (IDF criteria). 3. No evidence of any chronic inflammation. Exclusion Criteria: 1. Age below 31 years or above 65 years. 2. Severely ill patient. 3. Patient taking medication for CAHD, lipid disorder (statins). CONCLUSION: We conducted a small study with fifty subjects from southern part of Tamilnadu which showed a significant rise of hsCRP and Lp(a) which are newer risk factor for cardio vascular disease in patients with Metabolic Syndrome which is on the rise in people in India due to sedentary life habit and unhealthy pattern of eating and living. hsCRP and Lp(a) both are significantly elevated in Metabolic Syndrome. At lower BMI itself hsCRP is significantly elevated. Smoking doesn’t reveal any significant association with hsCRP. Lp(a) is significantly associated with BMI, TC, and LDL. So large multicenter studies involving various people from various parts of Tamilnadu / India are needed with setting end points like adverse cardio vascular events are need of the hour.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Correlation, hs-CRP, Lp(a), Metabolic Syndrome.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 15 Sep 2020 04:00
Last Modified: 15 Sep 2020 13:05
URI: http://repository-tnmgrmu.ac.in/id/eprint/13162

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