Aruloli, M (2012) A Comparative Study to Evaluate the Efficacy of Dexmedetomidine and Clonidine in Epidural Anaesthesia with Ropivacaine for Lower Abdominal Surgeries. Masters thesis, Thanjavur Medical College, Thanjavur.
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Abstract
BACKGROUND: Dexmedetomidine is a relatively new alpha-2 agonist and like its predecessor-clonidine has proven to have antihypertensive effects, sedative, anxiolytic and analgesic properties. AIM OF THE STUDY: To compare the efficacy of dexmedetomidine and clonidine in epidural anaesthesia with ropivacaine for lower abdominal surgeries. STUDY DESIGN: A prospective, randomised, double blinded, case control study. METHODS: Fifty adult patients (age 20-60 years) of ASA I and II physical status were randomised into two groups to receive lumbar epidural anaesthesia either with 16ml of 0.75% ropivacaine and 1μg/kg dexmedetomidine in GROUP RD (n=25) or 16ml of 0.75% ropivacaine and 1μg/kg clonidine in GROUP RC (n=25). They were observed for onset of epidural block, duration of analgesia and side effects. The Chi square test was used to analyse the data and a ‘p’ value <0.05 was considered significant. RESULTS: The onset of sensory block at T10 sensory level was 10.7±2.1min in GROUP RD and 11.4±1.8min in GROUP RC (p>0.05). The duration of analgesia was more in GROUP RD (277.7±30.4 min) than in GROUP RC (261.0±33.6 min) which was statistically significant (p<0.05). The level of sedation and other side effects were similar between the two groups. CONCLUSION: Dexmedetomidine provides a longer duration of analgesia when compared to clonidine when given via epidural route with ropivacaine without significant increase in side effects.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Dexmedetomidine, clonidine, analgesia, epidural, ropivacaine. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Sep 2020 02:37 |
| Last Modified: | 15 Sep 2020 02:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13156 |
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