Manonmani, M (2013) A Study of Serum Soluble Cd40 Ligand Level in Patients with Acute Coronary Syndrome. Masters thesis, Thanjavur Medical College, Thanjavur.
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Abstract
INTRODUCTION : Coronary heart disease is an impairment of heart function due to inadequate blood flow to the heart. It is the most common cause of death worldwide by 2020. Serum sCD40L is an inflammatory marker. It is released from the platelets as soon as the onset of the chest pain. It is a strong predictor of cardio vascular risk factor. AIMS AND OBJECTIVES : To estimate Serum sCD40Ligand, Serum CK-MB, Serum Lipid Parameters, Serum LDH, and Serum AST levels in patients with ACS. MATERIALS AND METHODS : Study group comprised of 50 subjects were admitted in ICCU with ACS (33ST elevation MI, 4 Non ST elevation MI, 13 UA). 50 healthy sex and age matched subjects were taken as control groups. Venous blood samples were collected. Serum Soluble CD40Ligand was estimated by ELISA technique, Serum CK-MB estimated by Immuno inhibition method, Serum Lipid profile by enzymatic assay methods. Serum LDH by DKGC method, Serum AST by Modified IFCC method. RESULTS : Serum sCD40L(p<0.0001), Serum TC, Serum TGL, Serum LDL-C, Serum VLDL were significantly increased in the study group, significant decrease in Serum HDL-C (p<0.0001) in study group compared to control group. By using pearsons correlation there is positive correlation between Serum sCD40L and Serum CK-MB, Serum TC, Serum TGL(p<0.01) and negative correlation between Serum sCD40L and Serum HDLC (p<0.01). CONCLUSION : sCD40L can be used as a marker in individuals with Acute Coronary Artery disease. Biochemical markers such as Serum CK-MB, cardiac Troponin-I, and Myoglobin are used in the clinical setting to asses MI. However, elevation of these markers indicate myocardial necrosis and in the absence of necrosis these markers are not elevated. Serum sCD40L is a marker of inflammatory thrombotic activity that is expressed within seconds, after platelet activation. Platelet activation and elevated fibrinogen level are associated with increased risk of Coronary thrombosis which is the gravest complication of atherosclerosis. Since ACS is complicated by both myocardial necrosis and inflammation, assessment of both the processes may allow a better assessment of the disease. Early intervention using anti-inflammatory drugs can be tried to prevent the progression of infarct size. This helps in reducing the morbidity and mortality from acute coronary syndrome.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | sCD40L ; MI ; CK-MB ; Lipid Parameters ; Acute Coronary Syndrome. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 11 Aug 2017 01:56 |
| Last Modified: | 11 Aug 2017 01:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1312 |
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