Study of Etiology of Late Onset Seizures in Coimbatore Medical College Hospital

Sandeep, U (2012) Study of Etiology of Late Onset Seizures in Coimbatore Medical College Hospital. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND & OBJECTIVES: To study the etiological profile of seizures in patients aged 60 and above, by means of history, clinical examination and investigations. METHOD: 100 patients with seizures who were above 60 years, attending the Medicine and Neurology OPD and elderly inpatients with seizures admitted under the departments of Medicine or Neurology at Coimbatore Medical College Hospital from 1st of September 2009 were studied. On the basis of history, clinical examination, blood investigations and radiological investigations, the etiology of the seizures was identified. RESULTS: In our study, 62% of the elderly patients comprised of males and 38% of females. 82% of the patients were in the age group of 60 – 74 years and 18% were above 75 years of age. The most common etiology of seizures was cerebrovascular accidents (42%), followed by central nervous system infections (16%), metabolic derangements (12%), tumours (7%), poisoning (1%). In 22% of the patients, no cause could be found. The most common cause of seizures, i. e, cerebrovascular events, could further be subgrouped into infarcts (comprising 69%) and haemorrhage (comprising 28.6%). Of the infarcts, 69% were old infarcts and only 31% were fresh infarcts. The commonest type of seizures was generalised type seen in 59% of the patients and partial seizures accounted for 41% (including focal seizures with no dyscognition, focal seizures with dyscognition, focal onset with generalisation). INTERPRETATION & CONCLUSION: There was no significant difference in the etiological profile between male and female patients. Generalised seizures were the most frequent type of seizure. The commonest etiology of seizures was a cerebrovascular accident, under which category; infarctions were more numerous than haemorrhage. Most infarcts were old. Infections accounted for a significant number of cases of seizures. Tuberculous meningoencephalitis was most common among them, followed by neurocysticercosis and bacterial meningoenephalitis. Other causes noted were metabolic derangements, tumours and poisoning.

Item Type: Thesis (Masters)
Additional Information: Reg.No.20091220
Uncontrolled Keywords: Etiology, Elderly, Epilepsy, Seizures, Generalised tonic clonic seizures, Generalised seizures, Partial Seizures, Focal seizures with dyscognitive features, Focal seizures with no dyscognitive features, focal seizures with generalisation, Neurocysticercosis.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 12 Sep 2020 16:55
Last Modified: 12 Sep 2020 16:55

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